Chlorine in PDB 4xuz: Structure of Ctx-M-15 Bound to Rpx-7009 at 1.5 A

All present enzymatic activity of Structure of Ctx-M-15 Bound to Rpx-7009 at 1.5 A:
3.5.2.6;

The structure of Structure of Ctx-M-15 Bound to Rpx-7009 at 1.5 A, PDB code: 4xuz was solved by M.C.Clifton, A.Gardberg, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 1.50
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	44.840, 45.810, 116.850, 90.00, 90.00, 90.00
R / Rfree (%)	13.2 / 14.7

The binding sites of Chlorine atom in the Structure of Ctx-M-15 Bound to Rpx-7009 at 1.5 A (pdb code 4xuz). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structure of Ctx-M-15 Bound to Rpx-7009 at 1.5 A, PDB code: 4xuz:

Chlorine binding site 1 out of 1 in the Structure of Ctx-M-15 Bound to Rpx-7009 at 1.5 A


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of Ctx-M-15 Bound to Rpx-7009 at 1.5 A within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl301 b:9.1 occ:1.00 O A:HOH518 3.2 11.2 1.0 N A:ALA202 3.3 8.2 1.0 CA A:PRO201 3.7 7.4 1.0 C A:PRO201 4.0 7.5 1.0 CB A:ALA202 4.0 9.2 1.0 CB A:PRO201 4.1 7.4 1.0 CA A:ALA202 4.2 8.7 1.0 N A:PRO201 5.0 7.0 1.0

S.J.Hecker, K.R.Reddy, M.Totrov, G.C.Hirst, O.Lomovskaya, D.C.Griffith, P.King, R.Tsivkovski, D.Sun, M.Sabet, Z.Tarazi, M.C.Clifton, K.Atkins, A.Raymond, K.T.Potts, J.Abendroth, S.H.Boyer, J.S.Loutit, E.E.Morgan, S.Durso, M.N.Dudley. Discovery of A Cyclic Boronic Acid Beta-Lactamase Inhibitor (RPX7009) with Utility Vs Class A Serine Carbapenemases. J.Med.Chem. 2015.
ISSN: ISSN 0022-2623
PubMed: 25782055
DOI: 10.1021/ACS.JMEDCHEM.5B00127