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Chlorine in PDB 4xxw: Crystal Structure of Mouse Cadherin-23 EC1-2 and Protocadherin-15 EC1- 2 Splice Variant

Protein crystallography data

The structure of Crystal Structure of Mouse Cadherin-23 EC1-2 and Protocadherin-15 EC1- 2 Splice Variant, PDB code: 4xxw was solved by Y.Narui, M.Sotomayor, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.26
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 157.746, 57.789, 155.264, 90.00, 99.17, 90.00
R / Rfree (%) 18.7 / 23.3

Other elements in 4xxw:

The structure of Crystal Structure of Mouse Cadherin-23 EC1-2 and Protocadherin-15 EC1- 2 Splice Variant also contains other interesting chemical elements:

Calcium (Ca) 14 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Mouse Cadherin-23 EC1-2 and Protocadherin-15 EC1- 2 Splice Variant (pdb code 4xxw). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Mouse Cadherin-23 EC1-2 and Protocadherin-15 EC1- 2 Splice Variant, PDB code: 4xxw:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 4xxw

Go back to Chlorine Binding Sites List in 4xxw
Chlorine binding site 1 out of 2 in the Crystal Structure of Mouse Cadherin-23 EC1-2 and Protocadherin-15 EC1- 2 Splice Variant


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Mouse Cadherin-23 EC1-2 and Protocadherin-15 EC1- 2 Splice Variant within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl1004

b:34.2
occ:1.00
O C:HOH1223 3.0 42.2 1.0
N C:ASP101 3.0 32.8 1.0
O B:HOH1115 3.2 20.3 1.0
N B:ALA20 3.4 29.4 1.0
CB B:ALA20 3.4 28.9 1.0
CD B:PRO19 3.6 34.1 1.0
CB B:PRO18 3.7 37.9 1.0
CA C:GLY100 3.8 31.7 1.0
CB C:ASP101 3.8 34.4 1.0
C C:GLY100 3.9 32.2 1.0
N B:PRO19 3.9 33.0 1.0
CA C:ASP101 4.0 34.0 1.0
CA B:ALA20 4.0 28.9 1.0
CG B:PRO19 4.1 33.9 1.0
O C:ASP101 4.3 32.8 1.0
C B:PRO18 4.3 34.8 1.0
C B:PRO19 4.4 29.5 1.0
CG B:PRO18 4.5 37.5 1.0
CA B:PRO19 4.5 31.1 1.0
CB B:PRO19 4.5 32.5 1.0
CA B:PRO18 4.6 37.5 1.0
O B:ALA20 4.6 29.7 1.0
C C:ASP101 4.6 33.9 1.0
CD1 C:LEU138 4.7 34.7 1.0
O C:VAL99 4.7 32.3 1.0
C B:ALA20 4.8 29.2 1.0
O C:HOH1186 4.8 43.1 1.0
O B:PRO18 5.0 33.8 1.0

Chlorine binding site 2 out of 2 in 4xxw

Go back to Chlorine Binding Sites List in 4xxw
Chlorine binding site 2 out of 2 in the Crystal Structure of Mouse Cadherin-23 EC1-2 and Protocadherin-15 EC1- 2 Splice Variant


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Mouse Cadherin-23 EC1-2 and Protocadherin-15 EC1- 2 Splice Variant within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1004

b:45.3
occ:1.00
O A:HOH1101 3.0 28.1 1.0
O D:HOH1201 3.1 46.5 1.0
N D:ASP101 3.2 33.5 1.0
N A:ALA20 3.2 42.1 1.0
CB A:ALA20 3.4 41.0 1.0
CD A:PRO19 3.7 46.7 1.0
N A:PRO19 3.8 46.9 1.0
CB D:ASP101 3.8 35.4 1.0
CB A:PRO18 3.8 55.1 1.0
CA A:ALA20 3.9 41.3 1.0
CA D:GLY100 4.0 33.2 1.0
CA D:ASP101 4.1 33.8 1.0
CG A:PRO19 4.1 45.9 1.0
C D:GLY100 4.1 33.2 1.0
C A:PRO19 4.3 43.2 1.0
O D:ASP101 4.3 33.6 1.0
CD1 D:LEU138 4.4 36.0 1.0
C A:PRO18 4.4 50.0 1.0
CA A:PRO19 4.4 44.9 1.0
CB A:PRO19 4.4 44.7 1.0
CG A:PRO18 4.4 55.8 1.0
O A:ALA20 4.6 42.2 1.0
C A:ALA20 4.7 41.3 1.0
NH2 A:ARG113 4.7 49.8 1.0
CA A:PRO18 4.7 54.0 1.0
C D:ASP101 4.7 33.6 1.0
O D:VAL99 4.7 32.1 1.0

Reference:

Y.Narui, M.Sotomayor. Tuning Inner-Ear Tip-Link Affinity Through Alternatively Spliced Variants of Protocadherin-15. Biochemistry V. 57 1702 2018.
ISSN: ISSN 1520-4995
PubMed: 29443515
DOI: 10.1021/ACS.BIOCHEM.7B01075
Page generated: Sat Dec 12 11:21:50 2020

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