Chlorine in PDB 4y3c: I304V 3D Polymerase Mutant of Emcv

All present enzymatic activity of I304V 3D Polymerase Mutant of Emcv:
2.7.7.48; 3.4.22.28; 3.6.1.15;

The structure of I304V 3D Polymerase Mutant of Emcv, PDB code: 4y3c was solved by N.Verdaguer, C.Ferrer-Orta, L.Vives-Adrian, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	138.96 / 3.20
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	232.332, 140.775, 171.838, 90.00, 126.03, 90.00
R / Rfree (%)	22 / 25

The binding sites of Chlorine atom in the I304V 3D Polymerase Mutant of Emcv (pdb code 4y3c). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the I304V 3D Polymerase Mutant of Emcv, PDB code: 4y3c:

Chlorine binding site 1 out of 1 in the I304V 3D Polymerase Mutant of Emcv


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of I304V 3D Polymerase Mutant of Emcv within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl505 b:69.7 occ:1.00 N D:GLY410 3.2 68.5 1.0 CB D:LEU412 3.5 69.3 1.0 CA D:GLY410 3.7 68.6 1.0 N D:LEU412 3.8 68.5 1.0 N D:THR411 4.0 67.9 1.0 C D:GLY410 4.1 68.2 1.0 C D:PRO409 4.2 68.1 1.0 CE2 D:TYR407 4.2 67.8 1.0 CA D:LEU412 4.3 68.8 1.0 CA D:PRO409 4.4 68.1 1.0 C1 F:GOL502 4.5 89.7 1.0 CD2 D:LEU412 4.6 70.2 1.0 CG D:LEU412 4.7 69.5 1.0 NZ F:LYS354 4.8 76.0 1.0 C D:THR411 4.8 67.8 1.0 O D:GLY410 4.9 68.4 1.0 O1 F:GOL502 4.9 89.9 1.0 CA D:THR411 4.9 67.8 1.0 CD2 D:TYR407 4.9 67.5 1.0

L.Van Der Linden, L.Vives-Adrian, B.Selisko, C.Ferrer-Orta, X.Liu, K.Lanke, R.Ulferts, A.M.De Palma, F.Tanchis, N.Goris, D.Lefebvre, K.De Clercq, P.Leyssen, C.Lacroix, G.Purstinger, B.Coutard, B.Canard, D.D.Boehr, J.J.Arnold, C.E.Cameron, N.Verdaguer, J.Neyts, F.J.M.Van Kuppeveld. The Rna Template Channel of the Rna-Dependent Rna Polymerase As A Target For Development of Antiviral Therapy of Multiple Genera Within A Virus Family. To Be Published.