Chlorine in PDB 4yeo: Triclinic Hewl Co-Crystallised with Cisplatin, Studied at A Data Collection Temperature of 150K - New Refinement

Enzymatic activity of Triclinic Hewl Co-Crystallised with Cisplatin, Studied at A Data Collection Temperature of 150K - New Refinement

All present enzymatic activity of Triclinic Hewl Co-Crystallised with Cisplatin, Studied at A Data Collection Temperature of 150K - New Refinement:
3.2.1.17;

Protein crystallography data

The structure of Triclinic Hewl Co-Crystallised with Cisplatin, Studied at A Data Collection Temperature of 150K - New Refinement, PDB code: 4yeo was solved by I.G.Shabalin, Z.Dauter, M.Jaskolski, W.Minor, A.Wlodawer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	29.26 / 0.98
*Space group*	P 1
*Cell size a, b, c (Å), α, β, γ (°)*	26.998, 31.807, 34.072, 89.08, 72.00, 67.81
*R / R_free (%)*	11.2 / 13.1

Other elements in 4yeo:

The structure of Triclinic Hewl Co-Crystallised with Cisplatin, Studied at A Data Collection Temperature of 150K - New Refinement also contains other interesting chemical elements:

Platinum

(Pt)

5 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Triclinic Hewl Co-Crystallised with Cisplatin, Studied at A Data Collection Temperature of 150K - New Refinement (pdb code 4yeo). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Triclinic Hewl Co-Crystallised with Cisplatin, Studied at A Data Collection Temperature of 150K - New Refinement, PDB code: 4yeo:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 4yeo

Go back to

Chlorine Binding Sites List in 4yeo

Chlorine binding site 1 out of 2 in the Triclinic Hewl Co-Crystallised with Cisplatin, Studied at A Data Collection Temperature of 150K - New Refinement

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Triclinic Hewl Co-Crystallised with Cisplatin, Studied at A Data Collection Temperature of 150K - New Refinement within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl201 b:7.7 occ:0.25	CL2	A:CPT201	0.0	7.7	0.2
	O	A:HOH429	2.2	11.0	0.8
	PT1	A:CPT201	2.3	5.8	0.2
	O	A:HOH497	2.9	21.7	1.0
	CL1	A:CPT201	3.3	7.6	0.2
	NE2	A:HIS15	3.3	18.0	0.6
	CD2	A:HIS15	3.8	15.7	0.6
	O	A:ARG14	4.0	9.6	1.0
	CD2	A:HIS15	4.0	15.3	0.4
	CE1	A:HIS15	4.0	19.4	0.6
	O	A:HOH408	4.0	15.9	1.0
	O	A:HOH430	4.1	10.7	0.8
	O	A:HOH451	4.1	12.3	0.5
	CB	A:ARG14	4.1	8.8	1.0
	NE2	A:HIS15	4.1	16.8	0.4
	N1	A:CPT201	4.3	7.4	0.2
	O	A:HOH451	4.4	12.0	0.5
	CD	A:ARG14	4.5	11.2	1.0
	C	A:ARG14	4.5	7.8	1.0
	CG	A:HIS15	4.6	15.9	0.6
	PT	A:PT202	4.7	12.7	0.2
	ND1	A:HIS15	4.7	17.6	0.6
	CG	A:ARG14	4.9	9.8	1.0
	NE	A:ARG14	4.9	11.6	1.0
	CG	A:HIS15	5.0	15.3	0.4
	CA	A:ARG14	5.0	7.7	1.0

Chlorine binding site 2 out of 2 in 4yeo

Go back to

Chlorine Binding Sites List in 4yeo

Chlorine binding site 2 out of 2 in the Triclinic Hewl Co-Crystallised with Cisplatin, Studied at A Data Collection Temperature of 150K - New Refinement

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Triclinic Hewl Co-Crystallised with Cisplatin, Studied at A Data Collection Temperature of 150K - New Refinement within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl201 b:7.6 occ:0.25	CL1	A:CPT201	0.0	7.6	0.2
	PT1	A:CPT201	2.3	5.8	0.2
	O	A:HOH429	2.6	11.0	0.8
	N1	A:CPT201	3.1	7.4	0.2
	CL2	A:CPT201	3.3	7.7	0.2
	PT	A:PT202	3.3	12.7	0.2
	NE	A:ARG14	3.7	11.6	1.0
	CD	A:ARG14	4.0	11.2	1.0
	NE2	A:HIS15	4.2	18.0	0.6
	O	A:HOH451	4.4	12.0	0.5
	NE2	A:HIS15	4.6	16.8	0.4
	O	A:HOH497	4.6	21.7	1.0
	CZ	A:ARG14	4.7	11.3	1.0
	O	A:HOH446	4.9	31.2	1.0
	NH2	A:ARG14	5.0	13.1	1.0

Reference:

I.G.Shabalin, Z.Dauter, M.Jaskolski, W.Minor, A.Wlodawer. Crystallography and Chemistry Should Always Go Together: A Cautionary Tale of Protein Complexes with Cisplatin and Carboplatin To Be Published.

Page generated: Fri Jul 26 04:02:35 2024

Last articles

As in 4PI2
As in 4PBE
As in 4OJR
As in 4O5B
As in 4O55
As in 4OSG
As in 4O0J
As in 4NLY
As in 4NLX
As in 4NSE

	© Copyright 2008-2020 by atomistry.com
Home \| Site Map \| Copyright \| Contact us \| Privacy