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Atomistry » Chlorine » PDB 4ylb-4ywj » 4ynd | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 4ylb-4ywj » 4ynd » |
Chlorine in PDB 4ynd: The Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2Enzymatic activity of The Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2
All present enzymatic activity of The Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2:
2.1.1.43; Protein crystallography data
The structure of The Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2, PDB code: 4ynd
was solved by
R.F.Sweis,
Z.Wang,
M.Algire,
C.H.Arrowsmith,
P.J.Brown,
G.C.Chiang,
J.Guo,
C.G.Jakob,
S.Kennedy,
F.Li,
N.B.Soni,
M.Vedadi,
W.N.Pappano,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4ynd:
The structure of The Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2 also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the The Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2
(pdb code 4ynd). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the The Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2, PDB code: 4ynd: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 4yndGo back to Chlorine Binding Sites List in 4ynd
Chlorine binding site 1 out
of 2 in the The Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 4yndGo back to Chlorine Binding Sites List in 4ynd
Chlorine binding site 2 out
of 2 in the The Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2
Mono view Stereo pair view
Reference:
R.F.Sweis,
Z.Wang,
M.Algire,
C.H.Arrowsmith,
P.J.Brown,
G.C.Chiang,
J.Guo,
C.G.Jakob,
S.Kennedy,
F.Li,
N.B.Soni,
M.Vedadi,
W.N.Pappano.
The Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2 Acs Med.Chem.Lett. 2015.
Page generated: Sat Dec 12 11:26:05 2020
ISSN: ISSN 0022-2623 DOI: 10.1021/ACSMEDCHEMLETT.5B00124 |
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