Atomistry » Chlorine » PDB 4z6v-4zg7 » 4zcg
Atomistry »
  Chlorine »
    PDB 4z6v-4zg7 »
      4zcg »

Chlorine in PDB 4zcg: Crystal Structure of Human GGT1 in Complex with Glutamate (with All Atoms of Glutamate)

Enzymatic activity of Crystal Structure of Human GGT1 in Complex with Glutamate (with All Atoms of Glutamate)

All present enzymatic activity of Crystal Structure of Human GGT1 in Complex with Glutamate (with All Atoms of Glutamate):
2.3.2.2; 3.4.19.13; 3.4.19.14;

Protein crystallography data

The structure of Crystal Structure of Human GGT1 in Complex with Glutamate (with All Atoms of Glutamate), PDB code: 4zcg was solved by S.Terzyan, M.Hanigan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 40.02 / 2.22
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 105.242, 125.230, 104.061, 90.00, 90.00, 90.00
R / Rfree (%) 14.6 / 18.5

Other elements in 4zcg:

The structure of Crystal Structure of Human GGT1 in Complex with Glutamate (with All Atoms of Glutamate) also contains other interesting chemical elements:

Sodium (Na) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Human GGT1 in Complex with Glutamate (with All Atoms of Glutamate) (pdb code 4zcg). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Human GGT1 in Complex with Glutamate (with All Atoms of Glutamate), PDB code: 4zcg:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 4zcg

Go back to Chlorine Binding Sites List in 4zcg
Chlorine binding site 1 out of 2 in the Crystal Structure of Human GGT1 in Complex with Glutamate (with All Atoms of Glutamate)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human GGT1 in Complex with Glutamate (with All Atoms of Glutamate) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl606

b:27.3
occ:1.00
NH2 B:ARG409 3.1 30.4 1.0
O B:HOH1215 3.1 22.4 1.0
N A:LEU213 3.2 25.5 1.0
C A:LEU210 3.3 28.6 1.0
N A:GLN212 3.3 28.0 1.0
CA A:LEU210 3.4 27.5 1.0
N A:PRO211 3.5 29.0 1.0
CB A:GLN212 3.7 31.4 1.0
CB A:LEU210 3.7 27.4 1.0
O A:LEU210 3.7 29.0 1.0
CD A:PRO211 3.7 27.4 1.0
CA A:GLN212 3.8 28.0 1.0
OE1 A:GLN212 3.9 36.9 1.0
CD2 A:LEU210 3.9 25.4 1.0
C A:GLN212 4.0 25.9 1.0
CB A:LEU213 4.0 26.3 1.0
CG1 A:VAL194 4.1 33.8 1.0
CZ B:ARG409 4.1 30.0 1.0
CA B:GLY414 4.1 26.4 1.0
NE B:ARG409 4.1 28.1 1.0
CA A:LEU213 4.2 26.1 1.0
C A:PRO211 4.2 25.9 1.0
CG A:LEU213 4.3 27.4 1.0
CA A:PRO211 4.4 28.6 1.0
CG A:LEU210 4.5 25.9 1.0
CD A:GLN212 4.6 33.4 1.0
O B:GLY414 4.7 26.2 1.0
N A:LEU210 4.7 28.8 1.0
CG A:GLN212 4.8 32.6 1.0
CG A:PRO211 4.8 28.2 1.0
CD1 A:LEU213 4.9 27.9 1.0
C B:GLY414 4.9 26.6 1.0
CB A:VAL194 5.0 33.7 1.0

Chlorine binding site 2 out of 2 in 4zcg

Go back to Chlorine Binding Sites List in 4zcg
Chlorine binding site 2 out of 2 in the Crystal Structure of Human GGT1 in Complex with Glutamate (with All Atoms of Glutamate)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Human GGT1 in Complex with Glutamate (with All Atoms of Glutamate) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl607

b:55.5
occ:1.00
OD2 A:ASP46 2.9 31.2 1.0
O B:HOH1244 3.0 33.8 1.0
NE2 B:GLN545 3.0 25.4 1.0
N B:HIS383 3.1 21.2 1.0
CB A:ASP46 3.5 30.2 1.0
CA B:ALA382 3.5 21.9 1.0
CG A:ASP46 3.6 31.8 1.0
CG1 B:VAL543 3.6 26.8 1.0
O B:HIS383 3.8 23.2 1.0
C B:ALA382 3.8 21.4 1.0
CB B:ALA472 3.9 27.7 1.0
CB B:ALA382 3.9 22.2 1.0
CB B:VAL543 4.1 26.7 1.0
NZ B:LYS562 4.1 36.2 1.0
CD B:LYS562 4.1 35.9 1.0
CA B:HIS383 4.2 22.2 1.0
CD B:GLN545 4.2 25.7 1.0
O B:HOH1248 4.3 30.9 1.0
O B:THR381 4.4 24.6 1.0
C B:HIS383 4.4 24.1 1.0
CB B:HIS383 4.5 22.4 1.0
OE1 B:GLN545 4.6 26.7 1.0
O B:VAL543 4.6 26.1 1.0
N B:ALA382 4.7 23.2 1.0
CE B:LYS562 4.7 36.6 1.0
OD1 A:ASP46 4.8 35.7 1.0
CA A:ASP46 4.9 28.2 1.0
CG2 B:VAL543 4.9 27.3 1.0
C B:THR381 5.0 25.3 1.0
N B:ALA472 5.0 25.6 1.0

Reference:

S.S.Terzyan, A.W.Burgett, A.Heroux, C.A.Smith, B.H.Mooers, M.H.Hanigan. Human Gamma-Glutamyl Transpeptidase 1: Structures of the Free Enzyme, Inhibitor-Bound Tetrahedral Transition States, and Glutamate-Bound Enzyme Reveal Novel Movement Within the Active Site During Catalysis. J.Biol.Chem. V. 290 17576 2015.
ISSN: ESSN 1083-351X
PubMed: 26013825
DOI: 10.1074/JBC.M115.659680
Page generated: Fri Jul 26 04:32:11 2024

Last articles

Ca in 5L9X
Ca in 5L9O
Ca in 5L9G
Ca in 5L9I
Ca in 5L8R
Ca in 5L8P
Ca in 5L89
Ca in 5L7F
Ca in 5L7P
Ca in 5L41
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy