Chlorine in PDB 4zhz: Endonuclease Inhibitor Bound to Influenza Strain H1N1 Polymerase Acidic Subunit N-Terminal Region with Expelling One of the Metal Ions in the Active Site

The structure of Endonuclease Inhibitor Bound to Influenza Strain H1N1 Polymerase Acidic Subunit N-Terminal Region with Expelling One of the Metal Ions in the Active Site, PDB code: 4zhz was solved by S.Fudo, N.Yamamoto, M.Nukaga, T.Odagiri, M.Tashiro, S.Neya, T.Hoshino, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	38.04 / 2.50
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	66.562, 66.562, 129.173, 90.00, 90.00, 90.00
R / Rfree (%)	22.2 / 27

The structure of Endonuclease Inhibitor Bound to Influenza Strain H1N1 Polymerase Acidic Subunit N-Terminal Region with Expelling One of the Metal Ions in the Active Site also contains other interesting chemical elements:

Manganese

(Mn)

1 atom

The binding sites of Chlorine atom in the Endonuclease Inhibitor Bound to Influenza Strain H1N1 Polymerase Acidic Subunit N-Terminal Region with Expelling One of the Metal Ions in the Active Site (pdb code 4zhz). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Endonuclease Inhibitor Bound to Influenza Strain H1N1 Polymerase Acidic Subunit N-Terminal Region with Expelling One of the Metal Ions in the Active Site, PDB code: 4zhz:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Endonuclease Inhibitor Bound to Influenza Strain H1N1 Polymerase Acidic Subunit N-Terminal Region with Expelling One of the Metal Ions in the Active Site


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Endonuclease Inhibitor Bound to Influenza Strain H1N1 Polymerase Acidic Subunit N-Terminal Region with Expelling One of the Metal Ions in the Active Site within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl301 b:78.9 occ:1.00 CLG A:4P8301 0.0 78.9 1.0 CAA A:4P8301 1.7 62.8 1.0 CAF A:4P8301 2.7 70.7 1.0 CAB A:4P8301 2.7 71.4 1.0 CAH A:4P8301 3.0 52.4 1.0 CAK A:4P8301 3.3 59.0 1.0 CAI A:4P8301 3.3 44.1 1.0 OAS A:4P8302 3.6 72.9 1.0 CG2 A:THR20 3.6 24.4 1.0 CG1 A:ILE38 3.8 28.2 1.0 CD1 A:ILE38 3.9 47.0 1.0 CAJ A:4P8302 4.0 70.3 1.0 CAE A:4P8301 4.0 67.0 1.0 CAC A:4P8301 4.0 57.6 1.0 CAM A:4P8301 4.3 58.2 1.0 CAJ A:4P8301 4.5 38.7 1.0 CAD A:4P8301 4.5 60.7 1.0 NAR A:4P8302 4.6 81.4 1.0 CAL A:4P8302 4.7 80.5 1.0 CG2 A:ILE38 4.7 35.8 1.0 CAH A:4P8302 4.8 58.0 1.0 CAI A:4P8302 4.8 63.1 1.0 CAO A:4P8301 4.9 40.1 1.0 CB A:ILE38 4.9 33.3 1.0

Chlorine binding site 2 out of 2 in the Endonuclease Inhibitor Bound to Influenza Strain H1N1 Polymerase Acidic Subunit N-Terminal Region with Expelling One of the Metal Ions in the Active Site


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Endonuclease Inhibitor Bound to Influenza Strain H1N1 Polymerase Acidic Subunit N-Terminal Region with Expelling One of the Metal Ions in the Active Site within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl302 b:89.1 occ:1.00 CLG A:4P8302 0.0 89.1 1.0 CAA A:4P8302 1.7 89.1 1.0 CAF A:4P8302 2.7 73.5 1.0 CAB A:4P8302 2.7 79.3 1.0 CAH A:4P8302 3.0 58.0 1.0 CAK A:4P8302 3.7 62.2 1.0 CAI A:4P8302 3.8 63.1 1.0 OAT A:4P8301 3.9 63.4 1.0 CAE A:4P8302 4.0 89.2 1.0 CAC A:4P8302 4.0 82.9 1.0 OE2 A:GLU119 4.2 40.7 1.0 CE A:LYS134 4.3 51.0 1.0 CAD A:4P8302 4.5 78.2 1.0 CD A:GLU119 4.5 39.2 1.0 CG2 A:ILE138 4.5 59.5 1.0 CB A:PHE105 4.6 61.8 1.0 CAD A:4P8301 4.7 60.7 1.0 NAR A:4P8301 4.8 57.7 1.0 OE1 A:GLU119 4.8 44.8 1.0 MN A:MN303 4.9 86.0 1.0 CD A:LYS134 4.9 50.0 1.0

S.Fudo, N.Yamamoto, M.Nukaga, T.Odagiri, M.Tashiro, S.Neya, T.Hoshino. Analysis of the Distinctive Binding Modes of Two Endonuclease Inhibitors to Influenza Virus Polymerase Acidic Subunit N-Terminal Region To Be Published.