Atomistry » Chlorine » PDB 4znr-4zyc » 4ztf
Atomistry »
  Chlorine »
    PDB 4znr-4zyc »
      4ztf »

Chlorine in PDB 4ztf: Crystal Structure of the Prototype Foamy Virus Intasome with A 2- Pyridinone Aminal Inhibitor

Protein crystallography data

The structure of Crystal Structure of the Prototype Foamy Virus Intasome with A 2- Pyridinone Aminal Inhibitor, PDB code: 4ztf was solved by D.J.Klein, S.Patel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 48.86 / 2.70
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 159.450, 159.450, 124.090, 90.00, 90.00, 90.00
R / Rfree (%) 19.1 / 21.5

Other elements in 4ztf:

The structure of Crystal Structure of the Prototype Foamy Virus Intasome with A 2- Pyridinone Aminal Inhibitor also contains other interesting chemical elements:

Fluorine (F) 1 atom
Magnesium (Mg) 3 atoms
Zinc (Zn) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of the Prototype Foamy Virus Intasome with A 2- Pyridinone Aminal Inhibitor (pdb code 4ztf). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of the Prototype Foamy Virus Intasome with A 2- Pyridinone Aminal Inhibitor, PDB code: 4ztf:

Chlorine binding site 1 out of 1 in 4ztf

Go back to Chlorine Binding Sites List in 4ztf
Chlorine binding site 1 out of 1 in the Crystal Structure of the Prototype Foamy Virus Intasome with A 2- Pyridinone Aminal Inhibitor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Prototype Foamy Virus Intasome with A 2- Pyridinone Aminal Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl404

b:58.4
occ:1.00
CL A:X2P404 0.0 58.4 1.0
C23 A:X2P404 1.7 49.9 1.0
C22 A:X2P404 2.7 48.8 1.0
C24 A:X2P404 2.7 45.0 1.0
F A:X2P404 2.9 53.2 1.0
N2 C:DG4 3.4 53.0 1.0
O A:PRO214 3.5 54.9 1.0
C2 C:DG4 3.5 53.7 1.0
CB A:GLU221 3.5 56.6 1.0
N1 C:DG4 3.5 54.1 1.0
C A:PRO214 3.6 54.7 1.0
CG A:GLU221 3.6 54.8 1.0
N3 D:DC16 3.6 53.0 1.0
N A:GLN215 3.7 53.6 1.0
C2 D:DC16 3.7 53.4 1.0
CA A:GLN215 3.9 54.3 1.0
O2 D:DC16 3.9 53.9 1.0
C21 A:X2P404 4.0 42.4 1.0
C19 A:X2P404 4.0 45.8 1.0
CB A:PRO214 4.0 56.4 1.0
C4 D:DC16 4.1 51.3 1.0
N3 C:DG4 4.2 54.0 1.0
N1 D:DC16 4.3 53.7 1.0
C6 C:DG4 4.3 54.0 1.0
CA A:PRO214 4.4 54.5 1.0
CG A:PRO214 4.4 55.0 1.0
C20 A:X2P404 4.5 42.6 1.0
CG A:GLN215 4.5 57.0 1.0
CD A:GLU221 4.6 56.4 1.0
N4 D:DC16 4.6 49.8 1.0
C5 D:DC16 4.7 51.5 1.0
C6 D:DC16 4.7 52.6 1.0
OE1 A:GLN215 4.8 59.6 1.0
CB A:GLN215 4.8 54.4 1.0
C4 C:DG4 4.8 54.5 1.0
CA A:GLY218 4.8 56.8 1.0
O6 C:DG4 4.8 53.8 1.0
C5 C:DG4 4.9 53.9 1.0
C A:GLN215 5.0 54.5 1.0
CA A:GLU221 5.0 54.9 1.0
C2' D:DC16 5.0 57.7 1.0

Reference:

I.T.Raheem, A.M.Walji, D.Klein, J.M.Sanders, D.A.Powell, P.Abeywickrema, G.Barbe, A.Bennet, S.D.Clas, D.Dubost, M.Embrey, J.Grobler, M.J.Hafey, T.J.Hartingh, D.J.Hazuda, M.D.Miller, K.P.Moore, N.Pajkovic, S.Patel, V.Rada, P.Rearden, J.D.Schreier, J.Sisko, T.G.Steele, J.F.Truchon, J.Wai, M.Xu, P.J.Coleman. Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance A Second Generation of Hiv-1 Integrase Strand Transfer Inhibitors. J.Med.Chem. V. 58 8154 2015.
ISSN: ISSN 0022-2623
PubMed: 26397965
DOI: 10.1021/ACS.JMEDCHEM.5B01037
Page generated: Fri Jul 11 23:54:49 2025

Last articles

Fe in 2YXO
Fe in 2YRS
Fe in 2YXC
Fe in 2YNM
Fe in 2YVJ
Fe in 2YP1
Fe in 2YU2
Fe in 2YU1
Fe in 2YQB
Fe in 2YOO
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy