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Atomistry » Chlorine » PDB 4zyc-5aa1 » 4zyi » |
Chlorine in PDB 4zyi: Discovery of Nvp-CGM097 - A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in P53WT Tumors: HDM2 (MDM2) Complexed with CPD2Protein crystallography data
The structure of Discovery of Nvp-CGM097 - A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in P53WT Tumors: HDM2 (MDM2) Complexed with CPD2, PDB code: 4zyi
was solved by
J.Kallen,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Discovery of Nvp-CGM097 - A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in P53WT Tumors: HDM2 (MDM2) Complexed with CPD2
(pdb code 4zyi). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Discovery of Nvp-CGM097 - A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in P53WT Tumors: HDM2 (MDM2) Complexed with CPD2, PDB code: 4zyi: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 4zyiGo back to Chlorine Binding Sites List in 4zyi
Chlorine binding site 1 out
of 2 in the Discovery of Nvp-CGM097 - A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in P53WT Tumors: HDM2 (MDM2) Complexed with CPD2
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 4zyiGo back to Chlorine Binding Sites List in 4zyi
Chlorine binding site 2 out
of 2 in the Discovery of Nvp-CGM097 - A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in P53WT Tumors: HDM2 (MDM2) Complexed with CPD2
Mono view Stereo pair view
Reference:
P.Holzer,
K.Masuya,
P.Furet,
J.Kallen,
T.Valat-Stachyra,
S.Ferretti,
J.Berghausen,
M.Bouisset-Leonard,
N.Buschmann,
C.Pissot-Soldermann,
C.Rynn,
S.Ruetz,
S.Stutz,
P.Chene,
S.Jeay,
F.Gessier.
Discovery of A Dihydroisoquinolinone Derivative (Nvp-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in P53WT Tumors. J.Med.Chem. V. 58 6348 2015.
Page generated: Fri Jul 26 04:54:08 2024
ISSN: ISSN 0022-2623 PubMed: 26181851 DOI: 10.1021/ACS.JMEDCHEM.5B00810 |
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