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Atomistry » Chlorine » PDB 5aa1-5aep » 5aab » |
Chlorine in PDB 5aab: Structure of C1156Y,L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with CrizotinibEnzymatic activity of Structure of C1156Y,L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with Crizotinib
All present enzymatic activity of Structure of C1156Y,L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with Crizotinib:
2.7.10.1; Protein crystallography data
The structure of Structure of C1156Y,L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with Crizotinib, PDB code: 5aab
was solved by
M.Mctigue,
Y.Deng,
W.Liu,
A.Brooun,
A.Stewart,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5aab:
The structure of Structure of C1156Y,L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with Crizotinib also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Structure of C1156Y,L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with Crizotinib
(pdb code 5aab). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Structure of C1156Y,L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with Crizotinib, PDB code: 5aab: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 5aabGo back to Chlorine Binding Sites List in 5aab
Chlorine binding site 1 out
of 2 in the Structure of C1156Y,L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with Crizotinib
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 5aabGo back to Chlorine Binding Sites List in 5aab
Chlorine binding site 2 out
of 2 in the Structure of C1156Y,L1198F Mutant Human Anaplastic Lymphoma Kinase in Complex with Crizotinib
Mono view Stereo pair view
Reference:
A.T.Shaw,
L.Friboulet,
I.Leshchiner,
J.F.Gainor,
S.Bergqvist,
A.Brooun,
B.J.Burke,
Y.Deng,
W.Liu,
L.Dardaei,
R.L.Frias,
K.R.Schultz,
J.Logan,
L.P.James,
T.Smeal,
S.Timofeevski,
R.Katayama,
A.J.Iafrate,
L.Le,
M.Mctigue,
G.Getz,
T.W.Johnson,
J.A.Engelman.
Resensitization to Crizotinib By the Lorlatinib Alk Resistance Mutation L1198F. N.Engl.J.Med. V. 374 54 2016.
Page generated: Sat Dec 12 11:29:59 2020
ISSN: ISSN 0028-4793 PubMed: 26698910 DOI: 10.1056/NEJMOA1508887 |
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