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Atomistry » Chlorine » PDB 5aa1-5aep » 5aae | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 5aa1-5aep » 5aae » |
Chlorine in PDB 5aae: Aurora A Kinase Bound to An Imidazopyridine Inhibitor (14D)Enzymatic activity of Aurora A Kinase Bound to An Imidazopyridine Inhibitor (14D)
All present enzymatic activity of Aurora A Kinase Bound to An Imidazopyridine Inhibitor (14D):
2.7.11.1; Protein crystallography data
The structure of Aurora A Kinase Bound to An Imidazopyridine Inhibitor (14D), PDB code: 5aae
was solved by
P.J.Mcintyre,
R.Bayliss,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Aurora A Kinase Bound to An Imidazopyridine Inhibitor (14D)
(pdb code 5aae). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Aurora A Kinase Bound to An Imidazopyridine Inhibitor (14D), PDB code: 5aae: Chlorine binding site 1 out of 1 in 5aaeGo back to Chlorine Binding Sites List in 5aae
Chlorine binding site 1 out
of 1 in the Aurora A Kinase Bound to An Imidazopyridine Inhibitor (14D)
Mono view Stereo pair view
Reference:
V.Bavetsias,
Y.Perez-Fuertes,
P.J.Mcintyre,
B.Atrash,
M.Kosmopoulou,
L.O'fee,
R.Burke,
C.Sun,
A.Faisal,
K.Bush,
S.Avery,
A.Henley,
F.I.Raynaud,
S.Linardopoulos,
R.Bayliss,
J.Blagg.
7-(Pyrazol-4-Yl)-3H-Imidazo[4,5-B]Pyridine-Based Derivatives For Kinase Inhibition: Co-Crystallisation Studies with Aurora-A Reveal Distinct Differences in the Orientation of the Pyrazole N1-Substituent. Bioorg.Med.Chem.Lett. V. 25 4203 2015.
Page generated: Sat Dec 12 11:30:01 2020
ISSN: ISSN 0960-894X PubMed: 26296477 DOI: 10.1016/J.BMCL.2015.08.003 |
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