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Atomistry » Chlorine » PDB 5afw-5anq » 5agt » |
Chlorine in PDB 5agt: Crystal Structure of the Leurs Editing Domain of Mycobacterium Tuberculosis in Complex with the Adduct (S)-3-(Aminomethyl)-4- Chloro-7-Ethoxybenzo[C][1,2]Oxaborol-1(3H)-Ol-AmpEnzymatic activity of Crystal Structure of the Leurs Editing Domain of Mycobacterium Tuberculosis in Complex with the Adduct (S)-3-(Aminomethyl)-4- Chloro-7-Ethoxybenzo[C][1,2]Oxaborol-1(3H)-Ol-Amp
All present enzymatic activity of Crystal Structure of the Leurs Editing Domain of Mycobacterium Tuberculosis in Complex with the Adduct (S)-3-(Aminomethyl)-4- Chloro-7-Ethoxybenzo[C][1,2]Oxaborol-1(3H)-Ol-Amp:
6.1.1.4; Protein crystallography data
The structure of Crystal Structure of the Leurs Editing Domain of Mycobacterium Tuberculosis in Complex with the Adduct (S)-3-(Aminomethyl)-4- Chloro-7-Ethoxybenzo[C][1,2]Oxaborol-1(3H)-Ol-Amp, PDB code: 5agt
was solved by
A.Palencia,
X.Li,
M.R.K.Alley,
C.Ding,
E.E.Easom,
V.Hernandez,
M.Meewan,
M.Mohan,
F.L.Rock,
S.G.Franzblau,
Y.Wang,
A.J.Lenaerts,
T.Parish,
C.B.Cooper,
M.G.Waters,
Z.Ma,
A.Mendoza,
D.Barros,
S.Cusack,
J.J.Plattner,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of the Leurs Editing Domain of Mycobacterium Tuberculosis in Complex with the Adduct (S)-3-(Aminomethyl)-4- Chloro-7-Ethoxybenzo[C][1,2]Oxaborol-1(3H)-Ol-Amp
(pdb code 5agt). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of the Leurs Editing Domain of Mycobacterium Tuberculosis in Complex with the Adduct (S)-3-(Aminomethyl)-4- Chloro-7-Ethoxybenzo[C][1,2]Oxaborol-1(3H)-Ol-Amp, PDB code: 5agt: Chlorine binding site 1 out of 1 in 5agtGo back to Chlorine Binding Sites List in 5agt
Chlorine binding site 1 out
of 1 in the Crystal Structure of the Leurs Editing Domain of Mycobacterium Tuberculosis in Complex with the Adduct (S)-3-(Aminomethyl)-4- Chloro-7-Ethoxybenzo[C][1,2]Oxaborol-1(3H)-Ol-Amp
Mono view Stereo pair view
Reference:
A.Palencia,
X.Li,
W.Bu,
W.Choi,
C.Z.Ding,
E.E.Easom,
L.Feng,
V.Hernandez,
P.Houston,
L.Liu,
M.Meewan,
M.Mohan,
F.L.Rock,
H.Sexton,
S.Zhang,
Y.Zhou,
B.Wan,
Y.Wang,
S.G.Franzblau,
L.Woolhiser,
V.Gruppo,
A.J.Lenaerts,
T.O'malley,
T.Parish,
C.B.Cooper,
M.G.Waters,
Z.Ma,
T.R.Ioerger,
J.C.Sacchettini,
J.Rullas,
I.Angulo-Barturen,
E.Perez-Herran,
A.Mendoza,
D.Barros,
S.Cusack,
J.J.Plattner,
M.R.K.Alley.
Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis That Target Leucyl-Trna Synthetase. Antimicrob.Agents Chemother. V. 60 6271 2016.
Page generated: Sat Dec 12 11:30:31 2020
ISSN: ISSN 0066-4804 PubMed: 27503647 DOI: 10.1128/AAC.01339-16 |
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