Atomistry » Chlorine » PDB 5afy-5anv » 5am9
Atomistry »
  Chlorine »
    PDB 5afy-5anv »
      5am9 »

Chlorine in PDB 5am9: Crystal Structure of the Angiotensin-1 Converting Enzyme N- Domain in Complex with Amyloid-Beta 10-16

Enzymatic activity of Crystal Structure of the Angiotensin-1 Converting Enzyme N- Domain in Complex with Amyloid-Beta 10-16

All present enzymatic activity of Crystal Structure of the Angiotensin-1 Converting Enzyme N- Domain in Complex with Amyloid-Beta 10-16:
3.4.15.1;

Protein crystallography data

The structure of Crystal Structure of the Angiotensin-1 Converting Enzyme N- Domain in Complex with Amyloid-Beta 10-16, PDB code: 5am9 was solved by G.Masuyer, K.M.Larmuth, R.G.Douglas, E.D.Sturrock, K.R.Acharya, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 113.27 / 1.80
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 73.348, 101.800, 113.950, 85.04, 85.55, 81.88
R / Rfree (%) 19.674 / 22.907

Other elements in 5am9:

The structure of Crystal Structure of the Angiotensin-1 Converting Enzyme N- Domain in Complex with Amyloid-Beta 10-16 also contains other interesting chemical elements:

Zinc (Zn) 4 atoms
Calcium (Ca) 2 atoms
Sodium (Na) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of the Angiotensin-1 Converting Enzyme N- Domain in Complex with Amyloid-Beta 10-16 (pdb code 5am9). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Crystal Structure of the Angiotensin-1 Converting Enzyme N- Domain in Complex with Amyloid-Beta 10-16, PDB code: 5am9:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in 5am9

Go back to Chlorine Binding Sites List in 5am9
Chlorine binding site 1 out of 4 in the Crystal Structure of the Angiotensin-1 Converting Enzyme N- Domain in Complex with Amyloid-Beta 10-16


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Angiotensin-1 Converting Enzyme N- Domain in Complex with Amyloid-Beta 10-16 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1002

b:21.7
occ:1.00
 NE A:ARG500 3.1 20.7 1.0
O A:HOH2170 3.1 19.0 1.0
OH A:TYR202 3.2 22.3 1.0
NH2 A:ARG500 3.5 22.4 1.0
CB A:ARG500 3.5 19.7 1.0
CB A:PRO385 3.7 23.1 1.0
CB A:PRO497 3.7 19.3 1.0
N A:ARG500 3.7 18.8 1.0
CZ A:ARG500 3.8 21.4 1.0
CE2 A:TYR202 3.8 23.1 1.0
CG2 A:ILE499 3.9 18.3 1.0
CE3 A:TRP201 3.9 26.7 1.0
CZ3 A:TRP201 3.9 26.5 1.0
CG A:PRO385 3.9 23.3 1.0
CZ A:TYR202 4.0 23.1 1.0
CG A:ARG500 4.0 19.6 1.0
CA A:ARG500 4.1 19.3 1.0
CD A:ARG500 4.2 20.1 1.0
CG A:PRO497 4.5 20.1 1.0
N A:ILE499 4.7 18.4 1.0
CD A:PRO385 4.7 23.2 1.0
C A:ILE499 4.7 18.5 1.0
C A:PRO497 4.7 18.8 1.0
CA A:PRO497 4.8 19.1 1.0
N A:TYR498 4.9 18.4 1.0
O A:HOH2296 4.9 19.3 1.0
O A:PRO497 5.0 19.1 1.0

Chlorine binding site 2 out of 4 in 5am9

Go back to Chlorine Binding Sites List in 5am9
Chlorine binding site 2 out of 4 in the Crystal Structure of the Angiotensin-1 Converting Enzyme N- Domain in Complex with Amyloid-Beta 10-16


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of the Angiotensin-1 Converting Enzyme N- Domain in Complex with Amyloid-Beta 10-16 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl1002

b:19.0
occ:1.00
 O B:HOH2155 3.0 19.2 1.0
OH B:TYR202 3.1 19.9 1.0
NE B:ARG500 3.2 16.8 1.0
NH2 B:ARG500 3.6 17.6 1.0
CB B:ARG500 3.6 16.3 1.0
CB B:PRO385 3.7 18.8 1.0
CB B:PRO497 3.7 16.8 1.0
CE1 B:TYR202 3.7 21.9 1.0
N B:ARG500 3.8 16.1 1.0
CE3 B:TRP201 3.8 25.6 1.0
CZ B:ARG500 3.9 17.3 1.0
CG B:PRO385 3.9 19.0 1.0
CZ3 B:TRP201 3.9 25.9 1.0
CZ B:TYR202 3.9 21.8 1.0
CG2 B:ILE499 4.0 17.1 1.0
CA B:ARG500 4.1 16.1 1.0
CG B:ARG500 4.1 16.3 1.0
CD B:ARG500 4.3 16.6 1.0
CG B:PRO497 4.5 17.0 1.0
N B:ILE499 4.7 16.6 1.0
C B:PRO497 4.7 16.3 1.0
O B:HOH2303 4.8 19.1 1.0
C B:ILE499 4.8 16.6 1.0
CD B:PRO385 4.8 19.1 1.0
CA B:PRO497 4.9 16.5 1.0
O B:PRO497 4.9 16.0 1.0

Chlorine binding site 3 out of 4 in 5am9

Go back to Chlorine Binding Sites List in 5am9
Chlorine binding site 3 out of 4 in the Crystal Structure of the Angiotensin-1 Converting Enzyme N- Domain in Complex with Amyloid-Beta 10-16


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of the Angiotensin-1 Converting Enzyme N- Domain in Complex with Amyloid-Beta 10-16 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl1002

b:17.7
occ:1.00
 O C:HOH2194 3.0 18.6 1.0
OH C:TYR202 3.0 17.9 1.0
NE C:ARG500 3.1 16.7 1.0
NH2 C:ARG500 3.5 16.8 1.0
CB C:ARG500 3.6 15.8 1.0
CB C:PRO385 3.7 16.8 1.0
CE2 C:TYR202 3.7 19.5 1.0
CB C:PRO497 3.7 16.3 1.0
N C:ARG500 3.7 15.8 1.0
CZ C:ARG500 3.8 16.7 1.0
CZ C:TYR202 3.8 19.1 1.0
CG C:PRO385 3.8 17.1 1.0
CE3 C:TRP201 3.9 26.8 1.0
CZ3 C:TRP201 3.9 26.9 1.0
CG2 C:ILE499 3.9 16.1 1.0
CG C:ARG500 4.0 16.4 1.0
CA C:ARG500 4.1 15.7 1.0
CD C:ARG500 4.2 16.4 1.0
CG C:PRO497 4.6 16.6 1.0
CD C:PRO385 4.7 17.1 1.0
N C:ILE499 4.7 15.5 1.0
C C:PRO497 4.7 16.4 1.0
C C:ILE499 4.8 15.8 1.0
CA C:PRO497 4.8 16.5 1.0
O C:HOH2371 4.9 18.8 1.0
N C:TYR498 5.0 16.0 1.0
CD2 C:TYR202 5.0 20.2 1.0
O C:PRO497 5.0 16.7 1.0

Chlorine binding site 4 out of 4 in 5am9

Go back to Chlorine Binding Sites List in 5am9
Chlorine binding site 4 out of 4 in the Crystal Structure of the Angiotensin-1 Converting Enzyme N- Domain in Complex with Amyloid-Beta 10-16


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of the Angiotensin-1 Converting Enzyme N- Domain in Complex with Amyloid-Beta 10-16 within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl1002

b:20.3
occ:1.00
 OH D:TYR202 3.0 19.2 1.0
NE D:ARG500 3.2 18.2 1.0
O D:HOH2164 3.2 19.7 1.0
NH2 D:ARG500 3.5 19.1 1.0
CB D:ARG500 3.6 17.3 1.0
CB D:PRO385 3.7 19.2 1.0
CB D:PRO497 3.7 18.6 1.0
CE2 D:TYR202 3.7 20.4 1.0
N D:ARG500 3.7 16.6 1.0
CZ D:ARG500 3.8 18.8 1.0
CZ D:TYR202 3.8 20.3 1.0
CG D:PRO385 3.9 19.5 1.0
CE3 D:TRP201 3.9 29.2 1.0
CG2 D:ILE499 3.9 16.9 1.0
CZ3 D:TRP201 3.9 29.9 1.0
CG D:ARG500 4.0 17.7 1.0
CA D:ARG500 4.1 16.8 1.0
CD D:ARG500 4.2 17.9 1.0
CG D:PRO497 4.5 18.8 1.0
CD D:PRO385 4.7 19.3 1.0
C D:ILE499 4.8 16.8 1.0
C D:PRO497 4.8 18.0 1.0
N D:ILE499 4.8 16.4 1.0
CA D:PRO497 4.8 18.6 1.0
O D:HOH2312 4.9 18.8 1.0
O D:PRO497 5.0 18.3 1.0

Reference:

K.M.Larmuth, G.Masuyer, R.G.Douglas, E.D.Sturrock, K.R.Acharya. The Kinetic and Structural Characterisation of Amyloid-Beta Metabolism By Human Angiotensin-1- Converting Enzyme (Ace) Febs J. V. 283 1060 2016.
ISSN: ISSN 1742-464X
PubMed: 26748546
DOI: 10.1111/FEBS.13647
Page generated: Fri Jul 26 05:19:51 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy