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Chlorine in PDB 5ap5: Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.

Enzymatic activity of Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.

All present enzymatic activity of Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.:
2.7.12.1;

Protein crystallography data

The structure of Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance., PDB code: 5ap5 was solved by M.D.Gurden, I.M.Westwood, A.Faisal, S.Naud, K.J.Cheung, C.Mcandrew, A.Wood, J.Schmitt, K.Boxall, G.Mak, P.Workman, R.Burke, S.Hoelder, J.Blagg, R.L.M.Van Montfort, S.Linardopoulos, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 59.73 / 2.80
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 70.320, 112.170, 113.180, 90.00, 90.00, 90.00
R / Rfree (%) 20.27 / 24.57

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. (pdb code 5ap5). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance., PDB code: 5ap5:

Chlorine binding site 1 out of 1 in 5ap5

Go back to Chlorine Binding Sites List in 5ap5
Chlorine binding site 1 out of 1 in the Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1795

b:86.2
occ:1.00
 CL A:7RO1795 0.0 86.2 1.0
C10 A:7RO1795 1.7 84.8 1.0
C11 A:7RO1795 2.6 85.8 1.0
C9 A:7RO1795 2.7 83.2 1.0
N3 A:7RO1795 2.9 77.9 1.0
O A:GLY605 3.2 92.5 1.0
O A:ASN606 3.8 0.2 1.0
CD1 A:ILE531 3.9 0.9 1.0
NE2 A:GLN541 3.9 0.1 1.0
CG1 A:ILE531 3.9 0.3 1.0
C12 A:7RO1795 3.9 90.8 1.0
SG A:CYS604 3.9 93.0 1.0
C17 A:7RO1795 4.0 84.9 1.0
C8 A:7RO1795 4.1 72.7 1.0
C A:GLY605 4.3 94.1 1.0
C16 A:7RO1795 4.5 88.1 1.0
C A:ASN606 4.5 0.8 1.0
CD A:GLN541 4.5 0.8 1.0
N2 A:7RO1795 4.6 72.8 1.0
CG2 A:ILE531 4.7 0.7 1.0
CA A:ASN606 4.9 98.2 1.0
CB A:ILE531 4.9 0.6 1.0
C18 A:7RO1795 5.0 68.0 1.0

Reference:

M.D.Gurden, I.M.Westwood, A.Faisal, S.Naud, K.J.Cheung, C.Mcandrew, A.Wood, J.Schmitt, K.Boxall, G.Mak, P.Workman, R.Burke, S.Hoelder, J.Blagg, R.L.M.Van Montfort, S.Linardopoulos. Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. Cancer Res. V. 75 3340 2015.
ISSN: ISSN 0008-5472
PubMed: 26202014
DOI: 10.1158/0008-5472.CAN-14-3272
Page generated: Fri Jul 26 05:23:01 2024

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