Chlorine in PDB 5bom: Dna Polymerase Beta Binary Complex with A Templating 5CLC

Enzymatic activity of Dna Polymerase Beta Binary Complex with A Templating 5CLC

All present enzymatic activity of Dna Polymerase Beta Binary Complex with A Templating 5CLC:
2.7.7.7;

Protein crystallography data

The structure of Dna Polymerase Beta Binary Complex with A Templating 5CLC, PDB code: 5bom was solved by B.D.Freudenthal, S.H.Wilson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.67 / 2.00
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 54.944, 79.547, 55.133, 90.00, 109.23, 90.00
R / Rfree (%) 19 / 21.4

Other elements in 5bom:

The structure of Dna Polymerase Beta Binary Complex with A Templating 5CLC also contains other interesting chemical elements:

Sodium (Na) 3 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Dna Polymerase Beta Binary Complex with A Templating 5CLC (pdb code 5bom). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Dna Polymerase Beta Binary Complex with A Templating 5CLC, PDB code: 5bom:

Chlorine binding site 1 out of 1 in 5bom

Go back to Chlorine Binding Sites List in 5bom
Chlorine binding site 1 out of 1 in the Dna Polymerase Beta Binary Complex with A Templating 5CLC


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Dna Polymerase Beta Binary Complex with A Templating 5CLC within 5.0Å range:
probe atom residue distance (Å) B Occ
T:Cl6

b:53.4
occ:1.00
CL5 T:4U36 0.0 53.4 1.0
C5 T:4U36 1.7 36.1 1.0
C4 T:4U36 2.7 33.8 1.0
C6 T:4U36 2.7 43.0 1.0
N4 T:4U36 3.0 38.0 1.0
O T:HOH205 3.4 33.5 1.0
O T:HOH235 3.4 44.5 1.0
O6 T:DG7 3.5 30.5 1.0
OP1 T:4U36 3.7 51.6 1.0
O A:HOH636 3.7 34.8 1.0
C6 T:DG7 4.0 35.6 1.0
N3 T:4U36 4.0 39.1 1.0
N1 T:4U36 4.1 44.7 1.0
OP2 T:4U36 4.3 68.4 1.0
C5 T:DG7 4.4 37.1 1.0
N7 T:DG7 4.5 40.7 1.0
P T:4U36 4.5 43.3 1.0
C2 T:4U36 4.6 35.4 1.0
N4 P:DC10 4.8 32.2 1.0
N1 T:DG7 4.8 30.5 1.0
ND2 A:ASN37 4.8 24.4 1.0
O5' T:4U36 4.9 47.4 1.0

Reference:

B.I.Fedeles, B.D.Freudenthal, E.Yau, V.Singh, S.C.Chang, D.Li, J.C.Delaney, S.H.Wilson, J.M.Essigmann. Intrinsic Mutagenic Properties of 5-Chlorocytosine: A Mechanistic Connection Between Chronic Inflammation and Cancer. Proc.Natl.Acad.Sci.Usa V. 112 E4571 2015.
ISSN: ESSN 1091-6490
PubMed: 26243878
DOI: 10.1073/PNAS.1507709112
Page generated: Sat Dec 12 11:32:24 2020

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