Chlorine in PDB 5bom: Dna Polymerase Beta Binary Complex with A Templating 5CLC

All present enzymatic activity of Dna Polymerase Beta Binary Complex with A Templating 5CLC:
2.7.7.7;

The structure of Dna Polymerase Beta Binary Complex with A Templating 5CLC, PDB code: 5bom was solved by B.D.Freudenthal, S.H.Wilson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	25.67 / 2.00
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	54.944, 79.547, 55.133, 90.00, 109.23, 90.00
R / Rfree (%)	19 / 21.4

The structure of Dna Polymerase Beta Binary Complex with A Templating 5CLC also contains other interesting chemical elements:

Sodium

(Na)

3 atoms

The binding sites of Chlorine atom in the Dna Polymerase Beta Binary Complex with A Templating 5CLC (pdb code 5bom). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Dna Polymerase Beta Binary Complex with A Templating 5CLC, PDB code: 5bom:

Chlorine binding site 1 out of 1 in the Dna Polymerase Beta Binary Complex with A Templating 5CLC


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Dna Polymerase Beta Binary Complex with A Templating 5CLC within 5.0Å range: probe atom residue distance (Å) B Occ T:Cl6 b:53.4 occ:1.00 CL5 T:4U36 0.0 53.4 1.0 C5 T:4U36 1.7 36.1 1.0 C4 T:4U36 2.7 33.8 1.0 C6 T:4U36 2.7 43.0 1.0 N4 T:4U36 3.0 38.0 1.0 O T:HOH205 3.4 33.5 1.0 O T:HOH235 3.4 44.5 1.0 O6 T:DG7 3.5 30.5 1.0 OP1 T:4U36 3.7 51.6 1.0 O A:HOH636 3.7 34.8 1.0 C6 T:DG7 4.0 35.6 1.0 N3 T:4U36 4.0 39.1 1.0 N1 T:4U36 4.1 44.7 1.0 OP2 T:4U36 4.3 68.4 1.0 C5 T:DG7 4.4 37.1 1.0 N7 T:DG7 4.5 40.7 1.0 P T:4U36 4.5 43.3 1.0 C2 T:4U36 4.6 35.4 1.0 N4 P:DC10 4.8 32.2 1.0 N1 T:DG7 4.8 30.5 1.0 ND2 A:ASN37 4.8 24.4 1.0 O5' T:4U36 4.9 47.4 1.0

B.I.Fedeles, B.D.Freudenthal, E.Yau, V.Singh, S.C.Chang, D.Li, J.C.Delaney, S.H.Wilson, J.M.Essigmann. Intrinsic Mutagenic Properties of 5-Chlorocytosine: A Mechanistic Connection Between Chronic Inflammation and Cancer. Proc.Natl.Acad.Sci.Usa V. 112 E4571 2015.
ISSN: ESSN 1091-6490
PubMed: 26243878
DOI: 10.1073/PNAS.1507709112