Chlorine in PDB 5bq8: Crystal Structure of Norrin, A Wnt Signalling Activator, Crystal Form II

The structure of Crystal Structure of Norrin, A Wnt Signalling Activator, Crystal Form II, PDB code: 5bq8 was solved by T.-H.Chang, F.-L.Hsieh, K.Harlos, E.Y.Jones, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	33.65 / 2.00
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	102.667, 53.059, 96.128, 90.00, 90.00, 90.00
R / Rfree (%)	23.3 / 24.8

The binding sites of Chlorine atom in the Crystal Structure of Norrin, A Wnt Signalling Activator, Crystal Form II (pdb code 5bq8). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Crystal Structure of Norrin, A Wnt Signalling Activator, Crystal Form II, PDB code: 5bq8:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in the Crystal Structure of Norrin, A Wnt Signalling Activator, Crystal Form II


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Norrin, A Wnt Signalling Activator, Crystal Form II within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl201 b:78.2 occ:1.00 O B:HOH322 2.7 77.3 1.0 NH1 B:ARG41 2.8 73.3 1.0 NE2 B:HIS43 3.0 51.4 1.0 OH B:TYR122 3.3 55.2 1.0 NH2 B:ARG41 3.5 72.3 1.0 CZ B:ARG41 3.6 73.5 1.0 CE1 B:HIS43 3.6 51.8 1.0 CE2 B:TYR122 4.0 49.9 1.0 CZ B:TYR122 4.1 52.9 1.0 CD2 B:HIS43 4.2 50.8 1.0 ND1 B:HIS43 4.8 51.4 1.0 NE B:ARG41 4.8 71.8 1.0

Chlorine binding site 2 out of 3 in the Crystal Structure of Norrin, A Wnt Signalling Activator, Crystal Form II


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Norrin, A Wnt Signalling Activator, Crystal Form II within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl201 b:77.7 occ:1.00 NH2 C:ARG41 3.9 49.7 1.0 NH1 C:ARG41 4.5 46.1 1.0 CZ C:ARG41 4.7 48.5 1.0 OH C:TYR122 4.8 51.2 1.0 NE2 C:HIS43 4.9 48.1 1.0 CE2 C:TYR122 5.0 47.0 1.0

Chlorine binding site 3 out of 3 in the Crystal Structure of Norrin, A Wnt Signalling Activator, Crystal Form II


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Norrin, A Wnt Signalling Activator, Crystal Form II within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl202 b:69.3 occ:1.00 NH1 D:ARG41 3.0 56.6 1.0 NE2 D:HIS43 3.0 62.2 1.0 OH D:TYR122 3.0 55.8 1.0 CE1 D:HIS43 3.5 63.2 1.0 NH2 D:ARG41 3.6 56.7 1.0 CZ D:ARG41 3.7 58.3 1.0 CZ D:TYR122 4.0 53.0 1.0 CE2 D:TYR122 4.0 53.1 1.0 CD2 D:HIS43 4.2 59.8 1.0 O D:HOH335 4.5 73.1 1.0 ND1 D:HIS43 4.7 61.3 1.0 NE D:ARG41 5.0 59.0 1.0

T.H.Chang, F.L.Hsieh, M.Zebisch, K.Harlos, J.Elegheert, E.Y.Jones. Structure and Functional Properties of Norrin Mimic Wnt For Signalling with FRIZZLED4, LRP5/6, and Proteoglycan. Elife V. 4 06554 2015.
ISSN: ESSN 2050-084X
PubMed: 26158506
DOI: 10.7554/ELIFE.06554