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Atomistry » Chlorine » PDB 5bv3-5c23 » 5c1w | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 5bv3-5c23 » 5c1w » |
Chlorine in PDB 5c1w: PDE10 Complexed with 4,6-Dichloro-2-Cyclopropyl-5-Methyl-PyrimidineEnzymatic activity of PDE10 Complexed with 4,6-Dichloro-2-Cyclopropyl-5-Methyl-Pyrimidine
All present enzymatic activity of PDE10 Complexed with 4,6-Dichloro-2-Cyclopropyl-5-Methyl-Pyrimidine:
3.1.4.17; 3.1.4.35; Protein crystallography data
The structure of PDE10 Complexed with 4,6-Dichloro-2-Cyclopropyl-5-Methyl-Pyrimidine, PDB code: 5c1w
was solved by
Y.Yan,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5c1w:
The structure of PDE10 Complexed with 4,6-Dichloro-2-Cyclopropyl-5-Methyl-Pyrimidine also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the PDE10 Complexed with 4,6-Dichloro-2-Cyclopropyl-5-Methyl-Pyrimidine
(pdb code 5c1w). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the PDE10 Complexed with 4,6-Dichloro-2-Cyclopropyl-5-Methyl-Pyrimidine, PDB code: 5c1w: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 5c1wGo back to![]() ![]()
Chlorine binding site 1 out
of 2 in the PDE10 Complexed with 4,6-Dichloro-2-Cyclopropyl-5-Methyl-Pyrimidine
![]() Mono view ![]() Stereo pair view
Chlorine binding site 2 out of 2 in 5c1wGo back to![]() ![]()
Chlorine binding site 2 out
of 2 in the PDE10 Complexed with 4,6-Dichloro-2-Cyclopropyl-5-Methyl-Pyrimidine
![]() Mono view ![]() Stereo pair view
Reference:
W.D.Shipe,
S.S.Sharik,
J.C.Barrow,
G.B.Mcgaughey,
C.R.Theberge,
J.M.Uslaner,
Y.Yan,
J.J.Renger,
S.M.Smith,
P.J.Coleman,
C.D.Cox.
Discovery and Optimization of A Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors Through Fragment Screening, Structure-Based Design, and Parallel Synthesis. J.Med.Chem. V. 58 7888 2015.
Page generated: Sat Dec 12 11:33:57 2020
ISSN: ISSN 0022-2623 PubMed: 26378882 DOI: 10.1021/ACS.JMEDCHEM.5B00983 |
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