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Chlorine in PDB 5c29: PDE10 Complexed with 6-Chloro-2-Cyclopropyl-5-Methyl-N-Propyl- Pyrimidin-4-AmineEnzymatic activity of PDE10 Complexed with 6-Chloro-2-Cyclopropyl-5-Methyl-N-Propyl- Pyrimidin-4-Amine
All present enzymatic activity of PDE10 Complexed with 6-Chloro-2-Cyclopropyl-5-Methyl-N-Propyl- Pyrimidin-4-Amine:
3.1.4.17; 3.1.4.35; Protein crystallography data
The structure of PDE10 Complexed with 6-Chloro-2-Cyclopropyl-5-Methyl-N-Propyl- Pyrimidin-4-Amine, PDB code: 5c29
was solved by
Y.Yan,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5c29:
The structure of PDE10 Complexed with 6-Chloro-2-Cyclopropyl-5-Methyl-N-Propyl- Pyrimidin-4-Amine also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the PDE10 Complexed with 6-Chloro-2-Cyclopropyl-5-Methyl-N-Propyl- Pyrimidin-4-Amine
(pdb code 5c29). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the PDE10 Complexed with 6-Chloro-2-Cyclopropyl-5-Methyl-N-Propyl- Pyrimidin-4-Amine, PDB code: 5c29: Chlorine binding site 1 out of 1 in 5c29Go back to Chlorine Binding Sites List in 5c29
Chlorine binding site 1 out
of 1 in the PDE10 Complexed with 6-Chloro-2-Cyclopropyl-5-Methyl-N-Propyl- Pyrimidin-4-Amine
Mono view Stereo pair view
Reference:
W.D.Shipe,
S.S.Sharik,
J.C.Barrow,
G.B.Mcgaughey,
C.R.Theberge,
J.M.Uslaner,
Y.Yan,
J.J.Renger,
S.M.Smith,
P.J.Coleman,
C.D.Cox.
Discovery and Optimization of A Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors Through Fragment Screening, Structure-Based Design, and Parallel Synthesis. J.Med.Chem. V. 58 7888 2015.
Page generated: Sat Dec 12 11:34:09 2020
ISSN: ISSN 0022-2623 PubMed: 26378882 DOI: 10.1021/ACS.JMEDCHEM.5B00983 |
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