Chlorine in PDB 5cbs: Crystal Structure of the GLUA2 Ligand-Binding Domain (S1S2J) in Complex with the Antagonist (R)-2-Amino-3-(3'-Hydroxybiphenyl-3-Yl) Propanoic Acid at 1.8A Resolution

The structure of Crystal Structure of the GLUA2 Ligand-Binding Domain (S1S2J) in Complex with the Antagonist (R)-2-Amino-3-(3'-Hydroxybiphenyl-3-Yl) Propanoic Acid at 1.8A Resolution, PDB code: 5cbs was solved by K.Frydenvang, J.S.Kastrup, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.35 / 1.80
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	61.468, 92.202, 197.476, 90.00, 90.00, 90.00
R / Rfree (%)	16.7 / 21.9

The binding sites of Chlorine atom in the Crystal Structure of the GLUA2 Ligand-Binding Domain (S1S2J) in Complex with the Antagonist (R)-2-Amino-3-(3'-Hydroxybiphenyl-3-Yl) Propanoic Acid at 1.8A Resolution (pdb code 5cbs). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of the GLUA2 Ligand-Binding Domain (S1S2J) in Complex with the Antagonist (R)-2-Amino-3-(3'-Hydroxybiphenyl-3-Yl) Propanoic Acid at 1.8A Resolution, PDB code: 5cbs:

Chlorine binding site 1 out of 1 in the Crystal Structure of the GLUA2 Ligand-Binding Domain (S1S2J) in Complex with the Antagonist (R)-2-Amino-3-(3'-Hydroxybiphenyl-3-Yl) Propanoic Acid at 1.8A Resolution


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the GLUA2 Ligand-Binding Domain (S1S2J) in Complex with the Antagonist (R)-2-Amino-3-(3'-Hydroxybiphenyl-3-Yl) Propanoic Acid at 1.8A Resolution within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl307 b:53.3 occ:1.00 O C:HOH627 3.1 17.0 1.0 N C:GLY138 3.5 19.1 1.0 CB C:SER137 3.7 14.8 1.0 CA C:SER137 3.7 16.5 1.0 O C:HOH611 3.7 19.8 1.0 C C:SER137 4.1 12.7 1.0 O C:HOH671 4.3 20.8 1.0 CA C:GLY138 4.6 13.2 1.0 O C:ASP136 4.9 10.7 1.0 OG C:SER137 5.0 15.0 1.0

E.Szymanska, K.Frydenvang, D.S.Pickering, C.Krintel, B.Nielsen, A.Kooshki, L.G.Zachariassen, L.Olsen, J.S.Kastrup, T.N.Johansen. Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at Ampa Receptors. J.Med.Chem. V. 59 448 2016.
ISSN: ISSN 0022-2623
PubMed: 26653877
DOI: 10.1021/ACS.JMEDCHEM.5B01666