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Atomistry » Chlorine » PDB 5cna-5cu2 » 5csw | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 5cna-5cu2 » 5csw » |
Chlorine in PDB 5csw: B-Raf in Complex with DabrafenibEnzymatic activity of B-Raf in Complex with Dabrafenib
All present enzymatic activity of B-Raf in Complex with Dabrafenib:
2.7.11.1; Protein crystallography data
The structure of B-Raf in Complex with Dabrafenib, PDB code: 5csw
was solved by
G.Bader,
H.Stadtmuller,
S.Steurer,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5csw:
The structure of B-Raf in Complex with Dabrafenib also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the B-Raf in Complex with Dabrafenib
(pdb code 5csw). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the B-Raf in Complex with Dabrafenib, PDB code: 5csw: Chlorine binding site 1 out of 1 in 5cswGo back to Chlorine Binding Sites List in 5csw
Chlorine binding site 1 out
of 1 in the B-Raf in Complex with Dabrafenib
Mono view Stereo pair view
Reference:
I.C.Waizenegger,
A.Baum,
S.Steurer,
H.Stadtmuller,
G.Bader,
O.Schaaf,
P.Garin-Chesa,
A.Schlattl,
N.Schweifer,
C.Haslinger,
F.Colbatzky,
S.Mousa,
A.Kalkuhl,
N.Kraut,
G.R.Adolf.
A Novel Raf Kinase Inhibitor with Dfg-Out-Binding Mode: High Efficacy in Braf-Mutant Tumor Xenograft Models in the Absence of Normal Tissue Hyperproliferation. Mol.Cancer Ther. V. 15 354 2016.
Page generated: Sat Dec 12 11:35:52 2020
ISSN: ESSN 1538-8514 PubMed: 26916115 DOI: 10.1158/1535-7163.MCT-15-0617 |
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