Atomistry » Chlorine » PDB 5cu4-5d0v » 5d0v
Atomistry »
  Chlorine »
    PDB 5cu4-5d0v »
      5d0v »

Chlorine in PDB 5d0v: Yeast 20S Proteasome BETA5-T1C Mutant in Complex with Carfilzomib

Enzymatic activity of Yeast 20S Proteasome BETA5-T1C Mutant in Complex with Carfilzomib

All present enzymatic activity of Yeast 20S Proteasome BETA5-T1C Mutant in Complex with Carfilzomib:
3.4.25.1;

Protein crystallography data

The structure of Yeast 20S Proteasome BETA5-T1C Mutant in Complex with Carfilzomib, PDB code: 5d0v was solved by E.M.Huber, M.Groll, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 15.00 / 2.90
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 135.170, 299.940, 144.940, 90.00, 112.56, 90.00
R / Rfree (%) 19.3 / 22

Other elements in 5d0v:

The structure of Yeast 20S Proteasome BETA5-T1C Mutant in Complex with Carfilzomib also contains other interesting chemical elements:

Magnesium (Mg) 8 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Yeast 20S Proteasome BETA5-T1C Mutant in Complex with Carfilzomib (pdb code 5d0v). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Yeast 20S Proteasome BETA5-T1C Mutant in Complex with Carfilzomib, PDB code: 5d0v:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in 5d0v

Go back to Chlorine Binding Sites List in 5d0v
Chlorine binding site 1 out of 4 in the Yeast 20S Proteasome BETA5-T1C Mutant in Complex with Carfilzomib


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Yeast 20S Proteasome BETA5-T1C Mutant in Complex with Carfilzomib within 5.0Å range:
probe atom residue distance (Å) B Occ
G:Cl302

b:48.6
occ:1.00
 OH H:TYR69 2.8 44.1 1.0
NH1 G:ARG111 3.0 40.4 1.0
ND2 G:ASN114 3.2 42.5 1.0
CD G:ARG111 3.6 40.3 1.0
CZ H:TYR69 3.6 43.1 1.0
CE2 H:TYR69 3.7 43.3 1.0
CB G:ASN114 3.8 42.6 1.0
CG G:ASN114 4.0 42.6 1.0
CZ G:ARG111 4.0 40.8 1.0
NE G:ARG111 4.3 40.6 1.0
CA G:ARG111 4.7 40.5 1.0
O G:ARG111 4.8 42.9 1.0
OD2 A:ASP87 4.9 47.9 1.0
CE1 H:TYR69 4.9 43.2 1.0
CG G:ARG111 4.9 39.9 1.0
CD2 H:TYR69 5.0 43.1 1.0

Chlorine binding site 2 out of 4 in 5d0v

Go back to Chlorine Binding Sites List in 5d0v
Chlorine binding site 2 out of 4 in the Yeast 20S Proteasome BETA5-T1C Mutant in Complex with Carfilzomib


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Yeast 20S Proteasome BETA5-T1C Mutant in Complex with Carfilzomib within 5.0Å range:
probe atom residue distance (Å) B Occ
N:Cl203

b:44.8
occ:1.00
 NH2 N:ARG45 3.0 43.2 1.0
NE2 N:GLN53 3.2 38.6 1.0
NH1 N:ARG45 3.4 43.1 1.0
CG2 N:THR31 3.5 46.4 1.0
CZ N:ARG45 3.6 42.0 1.0
C45 N:3BV201 4.0 37.2 1.0
CB N:ALA49 4.2 38.6 1.0
C46 N:3BV201 4.2 38.1 1.0
OD1 H:ASP120 4.2 71.9 1.0
CD N:GLN53 4.3 37.0 1.0
CG N:GLN53 4.5 36.7 1.0
O H:THR119 4.6 50.7 1.0
C44 N:3BV201 4.6 37.7 1.0
CA N:ALA49 4.7 39.2 1.0
OG1 N:THR20 4.8 44.4 1.0
CB a:TYR228 4.9 47.0 1.0
NE N:ARG45 4.9 40.5 1.0
O N:ALA49 5.0 40.3 1.0

Chlorine binding site 3 out of 4 in 5d0v

Go back to Chlorine Binding Sites List in 5d0v
Chlorine binding site 3 out of 4 in the Yeast 20S Proteasome BETA5-T1C Mutant in Complex with Carfilzomib


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Yeast 20S Proteasome BETA5-T1C Mutant in Complex with Carfilzomib within 5.0Å range:
probe atom residue distance (Å) B Occ
U:Cl301

b:49.2
occ:1.00
 OH V:TYR69 2.9 49.4 1.0
NH1 U:ARG111 3.0 50.6 1.0
ND2 U:ASN114 3.1 53.8 1.0
CB U:ASN114 3.6 50.1 1.0
CD U:ARG111 3.7 47.3 1.0
CZ V:TYR69 3.8 50.6 1.0
CE2 V:TYR69 3.8 50.5 1.0
CG U:ASN114 3.8 53.0 1.0
CZ U:ARG111 4.1 50.4 1.0
NE U:ARG111 4.3 49.4 1.0
CA U:ARG111 4.6 48.3 1.0
O U:ARG111 4.7 49.8 1.0
OD2 O:ASP87 4.9 45.6 1.0
CG U:ARG111 5.0 46.9 1.0

Chlorine binding site 4 out of 4 in 5d0v

Go back to Chlorine Binding Sites List in 5d0v
Chlorine binding site 4 out of 4 in the Yeast 20S Proteasome BETA5-T1C Mutant in Complex with Carfilzomib


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Yeast 20S Proteasome BETA5-T1C Mutant in Complex with Carfilzomib within 5.0Å range:
probe atom residue distance (Å) B Occ
b:Cl202

b:50.4
occ:1.00
 NE2 b:GLN53 3.0 39.9 1.0
NH2 b:ARG45 3.1 42.2 1.0
NH1 b:ARG45 3.5 43.3 1.0
CG2 b:THR31 3.6 49.7 1.0
CZ b:ARG45 3.8 41.9 1.0
OD1 V:ASP120 4.1 67.0 1.0
CB b:ALA49 4.1 40.6 1.0
CD b:GLN53 4.2 38.8 1.0
C45 b:3BV201 4.2 40.2 1.0
C46 b:3BV201 4.3 40.4 1.0
O V:THR119 4.4 46.8 1.0
CG b:GLN53 4.5 38.7 1.0
CA b:ALA49 4.7 41.1 1.0
OG1 b:THR20 4.8 42.7 1.0
CB M:TYR228 4.8 50.9 1.0
C44 b:3BV201 4.8 40.1 1.0
O b:ALA49 4.9 41.2 1.0

Reference:

E.M.Huber, W.Heinemeyer, X.Li, C.S.Arendt, M.Hochstrasser, M.Groll. A Unified Mechanism For Proteolysis and Autocatalytic Activation in the 20S Proteasome. Nat Commun V. 7 10900 2016.
ISSN: ESSN 2041-1723
PubMed: 26964885
DOI: 10.1038/NCOMMS10900
Page generated: Fri Jul 26 06:28:02 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy