Atomistry » Chlorine » PDB 5da3-5dif » 5dfr
Atomistry »
  Chlorine »
    PDB 5da3-5dif »
      5dfr »

Chlorine in PDB 5dfr: Crystal Structure of Unliganded Escherichia Coli Dihydrofolate Reductase. Ligand-Induced Conformational Changes and Cooperativity in Binding

Enzymatic activity of Crystal Structure of Unliganded Escherichia Coli Dihydrofolate Reductase. Ligand-Induced Conformational Changes and Cooperativity in Binding

All present enzymatic activity of Crystal Structure of Unliganded Escherichia Coli Dihydrofolate Reductase. Ligand-Induced Conformational Changes and Cooperativity in Binding:
1.5.1.3;

Protein crystallography data

The structure of Crystal Structure of Unliganded Escherichia Coli Dihydrofolate Reductase. Ligand-Induced Conformational Changes and Cooperativity in Binding, PDB code: 5dfr was solved by C.Bystroff, J.Kraut, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 2.30
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 68.730, 68.730, 83.350, 90.00, 90.00, 120.00
R / Rfree (%) n/a / n/a

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Unliganded Escherichia Coli Dihydrofolate Reductase. Ligand-Induced Conformational Changes and Cooperativity in Binding (pdb code 5dfr). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Crystal Structure of Unliganded Escherichia Coli Dihydrofolate Reductase. Ligand-Induced Conformational Changes and Cooperativity in Binding, PDB code: 5dfr:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in 5dfr

Go back to Chlorine Binding Sites List in 5dfr
Chlorine binding site 1 out of 3 in the Crystal Structure of Unliganded Escherichia Coli Dihydrofolate Reductase. Ligand-Induced Conformational Changes and Cooperativity in Binding


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Unliganded Escherichia Coli Dihydrofolate Reductase. Ligand-Induced Conformational Changes and Cooperativity in Binding within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl501

b:47.0
occ:1.00
 O A:HOH338 2.6 33.1 1.0
O A:HOH372 2.6 61.3 1.0
NZ A:LYS32 3.4 50.4 1.0
CE A:LYS32 3.9 45.8 1.0
CD2 A:LEU36 4.2 17.3 1.0
CD A:LYS32 5.0 38.2 1.0

Chlorine binding site 2 out of 3 in 5dfr

Go back to Chlorine Binding Sites List in 5dfr
Chlorine binding site 2 out of 3 in the Crystal Structure of Unliganded Escherichia Coli Dihydrofolate Reductase. Ligand-Induced Conformational Changes and Cooperativity in Binding


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Unliganded Escherichia Coli Dihydrofolate Reductase. Ligand-Induced Conformational Changes and Cooperativity in Binding within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl502

b:35.7
occ:1.00
 CB A:HIS114 2.9 34.9 1.0
CD2 A:HIS114 3.2 55.0 1.0
CG A:HIS114 3.3 52.3 1.0
OE2 A:GLU154 3.8 19.6 1.0
CA A:HIS114 3.9 27.1 1.0
N A:HIS114 4.1 18.9 1.0
CB A:LEU112 4.3 15.3 1.0
NE2 A:HIS114 4.5 57.9 1.0
CB A:GLU154 4.5 12.9 1.0
CL A:CL503 4.6 56.0 1.0
O A:HOH361 4.6 37.9 1.0
ND1 A:HIS114 4.7 53.7 1.0
C A:THR113 4.7 16.7 1.0
O A:CYS152 4.8 15.2 1.0
O A:HOH330 4.8 37.7 1.0
CD A:GLU154 4.9 18.5 1.0
CD1 A:LEU112 4.9 22.8 1.0

Chlorine binding site 3 out of 3 in 5dfr

Go back to Chlorine Binding Sites List in 5dfr
Chlorine binding site 3 out of 3 in the Crystal Structure of Unliganded Escherichia Coli Dihydrofolate Reductase. Ligand-Induced Conformational Changes and Cooperativity in Binding


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Unliganded Escherichia Coli Dihydrofolate Reductase. Ligand-Induced Conformational Changes and Cooperativity in Binding within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl503

b:56.0
occ:1.00
 OG A:SER138 4.0 21.9 1.0
OE2 A:GLU154 4.0 19.6 1.0
CD A:GLU154 4.1 18.5 1.0
SG A:CYS152 4.1 17.6 1.0
CZ A:PHE140 4.2 11.6 1.0
OE1 A:GLU154 4.5 21.9 1.0
CG A:GLU154 4.5 12.3 1.0
CL A:CL502 4.6 35.7 1.0
CE2 A:PHE140 4.6 18.4 1.0
CB A:GLU154 4.8 12.9 1.0
O A:HOH351 4.9 34.5 1.0

Reference:

C.Bystroff, J.Kraut. Crystal Structure of Unliganded Escherichia Coli Dihydrofolate Reductase. Ligand-Induced Conformational Changes and Cooperativity in Binding. Biochemistry V. 30 2227 1991.
ISSN: ISSN 0006-2960
PubMed: 1998681
DOI: 10.1021/BI00222A028
Page generated: Fri Jul 26 06:41:34 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy