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Atomistry » Chlorine » PDB 5dt9-5e1h » 5dxh | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 5dt9-5e1h » 5dxh » |
Chlorine in PDB 5dxh: P110ALPHA/P85ALPHA with Compound 5Enzymatic activity of P110ALPHA/P85ALPHA with Compound 5Protein crystallography data
The structure of P110ALPHA/P85ALPHA with Compound 5, PDB code: 5dxh
was solved by
T.P.Heffron,
R.A.Heald,
C.Ndubaku,
B.Q.Wei,
M.Augustin,
S.Do,
K.Edgar,
C.Eigenbrot,
L.Friedman,
E.Gancia,
P.S.Jackson,
G.Jones,
A.Kolesnikov,
L.B.Lee,
J.D.Lesnick,
C.Lewis,
N.Mclean,
M.Mortle,
J.Nonomiya,
J.Pang,
S.Price,
W.W.Prior,
L.Salphati,
S.Sideris,
S.Staben,
S.Steinbacher,
V.Tsui,
J.Wallin,
D.Sampath,
A.Olivero,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the P110ALPHA/P85ALPHA with Compound 5
(pdb code 5dxh). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the P110ALPHA/P85ALPHA with Compound 5, PDB code: 5dxh: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 5dxhGo back to Chlorine Binding Sites List in 5dxh
Chlorine binding site 1 out
of 2 in the P110ALPHA/P85ALPHA with Compound 5
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 5dxhGo back to Chlorine Binding Sites List in 5dxh
Chlorine binding site 2 out
of 2 in the P110ALPHA/P85ALPHA with Compound 5
Mono view Stereo pair view
Reference:
T.P.Heffron,
R.A.Heald,
C.Ndubaku,
B.Wei,
M.Augistin,
S.Do,
K.Edgar,
C.Eigenbrot,
L.Friedman,
E.Gancia,
P.S.Jackson,
G.Jones,
A.Kolesnikov,
L.B.Lee,
J.D.Lesnick,
C.Lewis,
N.Mclean,
M.Mortl,
J.Nonomiya,
J.Pang,
S.Price,
W.W.Prior,
L.Salphati,
S.Sideris,
S.T.Staben,
S.Steinbacher,
V.Tsui,
J.Wallin,
D.Sampath,
A.G.Olivero.
The Rational Design of Selective Benzoxazepin Inhibitors of the Alpha-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-Triazol-5-Yl)-5, 6-Dihydrobenzo[F]Imidazo[1,2-D][1,4]Oxazepin-9-Yl)Oxy) Propanamide (Gdc-0326). J.Med.Chem. V. 59 985 2016.
Page generated: Sat Dec 12 11:40:01 2020
ISSN: ISSN 0022-2623 PubMed: 26741947 DOI: 10.1021/ACS.JMEDCHEM.5B01483 |
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