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Atomistry » Chlorine » PDB 5e1x-5eac » 5e2o | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 5e1x-5eac » 5e2o » |
Chlorine in PDB 5e2o: Factor Xia in Complex with the Inhibitor 4-[(N-{(2E)-3-[5-Chloro-2- (1H-Tetrazol-1-Yl)Phenyl]Prop-2-Enoyl}-L-Phenylalanyl)Amino]Benzoic AcidEnzymatic activity of Factor Xia in Complex with the Inhibitor 4-[(N-{(2E)-3-[5-Chloro-2- (1H-Tetrazol-1-Yl)Phenyl]Prop-2-Enoyl}-L-Phenylalanyl)Amino]Benzoic Acid
All present enzymatic activity of Factor Xia in Complex with the Inhibitor 4-[(N-{(2E)-3-[5-Chloro-2- (1H-Tetrazol-1-Yl)Phenyl]Prop-2-Enoyl}-L-Phenylalanyl)Amino]Benzoic Acid:
3.4.21.27; Protein crystallography data
The structure of Factor Xia in Complex with the Inhibitor 4-[(N-{(2E)-3-[5-Chloro-2- (1H-Tetrazol-1-Yl)Phenyl]Prop-2-Enoyl}-L-Phenylalanyl)Amino]Benzoic Acid, PDB code: 5e2o
was solved by
A.Wei,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Factor Xia in Complex with the Inhibitor 4-[(N-{(2E)-3-[5-Chloro-2- (1H-Tetrazol-1-Yl)Phenyl]Prop-2-Enoyl}-L-Phenylalanyl)Amino]Benzoic Acid
(pdb code 5e2o). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Factor Xia in Complex with the Inhibitor 4-[(N-{(2E)-3-[5-Chloro-2- (1H-Tetrazol-1-Yl)Phenyl]Prop-2-Enoyl}-L-Phenylalanyl)Amino]Benzoic Acid, PDB code: 5e2o: Chlorine binding site 1 out of 1 in 5e2oGo back to Chlorine Binding Sites List in 5e2o
Chlorine binding site 1 out
of 1 in the Factor Xia in Complex with the Inhibitor 4-[(N-{(2E)-3-[5-Chloro-2- (1H-Tetrazol-1-Yl)Phenyl]Prop-2-Enoyl}-L-Phenylalanyl)Amino]Benzoic Acid
Mono view Stereo pair view
Reference:
L.M.Smith,
M.J.Orwat,
Z.Hu,
W.Han,
C.Wang,
K.A.Rossi,
P.J.Gilligan,
K.B.Pabbisetty,
H.Osuna,
J.R.Corte,
A.R.Rendina,
J.M.Luettgen,
P.C.Wong,
R.Narayanan,
T.W.Harper,
J.M.Bozarth,
E.J.Crain,
A.Wei,
V.Ramamurthy,
P.E.Morin,
B.Xin,
J.Zheng,
D.A.Seiffert,
M.L.Quan,
P.Y.Lam,
R.R.Wexler,
D.J.Pinto.
Novel Phenylalanine Derived Diamides As Factor Xia Inhibitors. Bioorg.Med.Chem.Lett. V. 26 472 2016.
Page generated: Sat Dec 12 11:40:18 2020
ISSN: ESSN 1464-3405 PubMed: 26704266 DOI: 10.1016/J.BMCL.2015.11.089 |
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