|
Atomistry » Chlorine » PDB 5e1x-5eac » 5e2p | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 5e1x-5eac » 5e2p » |
Chlorine in PDB 5e2p: Factor Xia in Complex with the Inhibitor N-[(1S)-1-Benzyl-2-[2-[5- Chloro-2-(Tetrazol-1-Yl)Phenyl]Ethylamino]-2-Oxo-Ethyl]-4-Hydroxy-2- Oxo-1H-Quinoline-6-CarboxamideEnzymatic activity of Factor Xia in Complex with the Inhibitor N-[(1S)-1-Benzyl-2-[2-[5- Chloro-2-(Tetrazol-1-Yl)Phenyl]Ethylamino]-2-Oxo-Ethyl]-4-Hydroxy-2- Oxo-1H-Quinoline-6-Carboxamide
All present enzymatic activity of Factor Xia in Complex with the Inhibitor N-[(1S)-1-Benzyl-2-[2-[5- Chloro-2-(Tetrazol-1-Yl)Phenyl]Ethylamino]-2-Oxo-Ethyl]-4-Hydroxy-2- Oxo-1H-Quinoline-6-Carboxamide:
3.4.21.27; Protein crystallography data
The structure of Factor Xia in Complex with the Inhibitor N-[(1S)-1-Benzyl-2-[2-[5- Chloro-2-(Tetrazol-1-Yl)Phenyl]Ethylamino]-2-Oxo-Ethyl]-4-Hydroxy-2- Oxo-1H-Quinoline-6-Carboxamide, PDB code: 5e2p
was solved by
A.Wei,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Factor Xia in Complex with the Inhibitor N-[(1S)-1-Benzyl-2-[2-[5- Chloro-2-(Tetrazol-1-Yl)Phenyl]Ethylamino]-2-Oxo-Ethyl]-4-Hydroxy-2- Oxo-1H-Quinoline-6-Carboxamide
(pdb code 5e2p). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Factor Xia in Complex with the Inhibitor N-[(1S)-1-Benzyl-2-[2-[5- Chloro-2-(Tetrazol-1-Yl)Phenyl]Ethylamino]-2-Oxo-Ethyl]-4-Hydroxy-2- Oxo-1H-Quinoline-6-Carboxamide, PDB code: 5e2p: Chlorine binding site 1 out of 1 in 5e2pGo back to Chlorine Binding Sites List in 5e2p
Chlorine binding site 1 out
of 1 in the Factor Xia in Complex with the Inhibitor N-[(1S)-1-Benzyl-2-[2-[5- Chloro-2-(Tetrazol-1-Yl)Phenyl]Ethylamino]-2-Oxo-Ethyl]-4-Hydroxy-2- Oxo-1H-Quinoline-6-Carboxamide
Mono view Stereo pair view
Reference:
L.M.Smith,
M.J.Orwat,
Z.Hu,
W.Han,
C.Wang,
K.A.Rossi,
P.J.Gilligan,
K.B.Pabbisetty,
H.Osuna,
J.R.Corte,
A.R.Rendina,
J.M.Luettgen,
P.C.Wong,
R.Narayanan,
T.W.Harper,
J.M.Bozarth,
E.J.Crain,
A.Wei,
V.Ramamurthy,
P.E.Morin,
B.Xin,
J.Zheng,
D.A.Seiffert,
M.L.Quan,
P.Y.Lam,
R.R.Wexler,
D.J.Pinto.
Novel Phenylalanine Derived Diamides As Factor Xia Inhibitors. Bioorg.Med.Chem.Lett. V. 26 472 2016.
Page generated: Sat Dec 12 11:40:19 2020
ISSN: ESSN 1464-3405 PubMed: 26704266 DOI: 10.1016/J.BMCL.2015.11.089 |
Last articlesZn in 8WB0Zn in 8WAX Zn in 8WAU Zn in 8WAZ Zn in 8WAY Zn in 8WAV Zn in 8WAW Zn in 8WAT Zn in 8W7M Zn in 8WD3 |
© Copyright 2008-2020 by atomistry.com | ||
Home | Site Map | Copyright | Contact us | Privacy |