Atomistry » Chlorine » PDB 5e1x-5eac » 5e4n
Atomistry »
  Chlorine »
    PDB 5e1x-5eac »
      5e4n »

Chlorine in PDB 5e4n: 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase From Mycobacterium Tuberculosis with D-Tyrosine Bound in the Tyrosine and Phenylalanine Binding Sites

Enzymatic activity of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase From Mycobacterium Tuberculosis with D-Tyrosine Bound in the Tyrosine and Phenylalanine Binding Sites

All present enzymatic activity of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase From Mycobacterium Tuberculosis with D-Tyrosine Bound in the Tyrosine and Phenylalanine Binding Sites:
2.5.1.54;

Protein crystallography data

The structure of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase From Mycobacterium Tuberculosis with D-Tyrosine Bound in the Tyrosine and Phenylalanine Binding Sites, PDB code: 5e4n was solved by S.Reichau, W.Jiao, E.J.Parker, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.37 / 2.05
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 205.739, 205.739, 66.644, 90.00, 90.00, 120.00
R / Rfree (%) 19.9 / 22.9

Other elements in 5e4n:

The structure of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase From Mycobacterium Tuberculosis with D-Tyrosine Bound in the Tyrosine and Phenylalanine Binding Sites also contains other interesting chemical elements:

Manganese (Mn) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase From Mycobacterium Tuberculosis with D-Tyrosine Bound in the Tyrosine and Phenylalanine Binding Sites (pdb code 5e4n). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase From Mycobacterium Tuberculosis with D-Tyrosine Bound in the Tyrosine and Phenylalanine Binding Sites, PDB code: 5e4n:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in 5e4n

Go back to Chlorine Binding Sites List in 5e4n
Chlorine binding site 1 out of 4 in the 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase From Mycobacterium Tuberculosis with D-Tyrosine Bound in the Tyrosine and Phenylalanine Binding Sites


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase From Mycobacterium Tuberculosis with D-Tyrosine Bound in the Tyrosine and Phenylalanine Binding Sites within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl502

b:61.9
occ:1.00
 N A:ALA141 3.4 24.4 1.0
CB A:ASP140 3.6 24.9 1.0
NH2 A:ARG135 3.8 59.8 1.0
CB A:ALA141 3.9 27.2 1.0
CA A:ASP140 4.0 24.8 1.0
C A:ASP140 4.2 24.5 1.0
CA A:ALA141 4.3 25.7 1.0
CG A:ASP140 4.6 25.5 1.0

Chlorine binding site 2 out of 4 in 5e4n

Go back to Chlorine Binding Sites List in 5e4n
Chlorine binding site 2 out of 4 in the 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase From Mycobacterium Tuberculosis with D-Tyrosine Bound in the Tyrosine and Phenylalanine Binding Sites


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase From Mycobacterium Tuberculosis with D-Tyrosine Bound in the Tyrosine and Phenylalanine Binding Sites within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl504

b:62.7
occ:1.00
 NH1 A:ARG49 3.6 39.4 1.0
NH2 A:ARG256 3.7 41.4 1.0
CZ A:ARG256 4.5 40.1 1.0
NH1 A:ARG256 4.6 40.0 1.0
CZ A:ARG49 4.7 39.3 1.0

Chlorine binding site 3 out of 4 in 5e4n

Go back to Chlorine Binding Sites List in 5e4n
Chlorine binding site 3 out of 4 in the 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase From Mycobacterium Tuberculosis with D-Tyrosine Bound in the Tyrosine and Phenylalanine Binding Sites


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase From Mycobacterium Tuberculosis with D-Tyrosine Bound in the Tyrosine and Phenylalanine Binding Sites within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl504

b:39.3
occ:1.00
 O A:HOH605 3.0 15.9 0.5
OG B:SER62 3.0 19.8 1.0
N B:SER62 3.2 18.2 1.0
CB B:SER62 3.4 18.2 1.0
CD B:PRO61 3.8 15.6 1.0
N B:PRO61 3.8 15.2 1.0
CB B:VAL60 3.9 14.8 1.0
CA B:SER62 3.9 17.9 1.0
CG2 B:VAL60 3.9 15.0 1.0
O A:HOH814 4.0 47.4 1.0
C B:PRO61 4.2 16.6 1.0
C B:VAL60 4.4 14.9 1.0
CA B:PRO61 4.4 16.0 1.0
CB B:PRO61 4.4 16.4 1.0
O B:HOH823 4.5 45.9 1.0
CG B:PRO61 4.6 15.8 1.0
CA B:VAL60 4.7 14.4 1.0
NH1 A:ARG100 4.8 22.1 0.5
CB A:SER189 4.8 30.4 1.0
CG1 B:VAL60 5.0 14.5 1.0

Chlorine binding site 4 out of 4 in 5e4n

Go back to Chlorine Binding Sites List in 5e4n
Chlorine binding site 4 out of 4 in the 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase From Mycobacterium Tuberculosis with D-Tyrosine Bound in the Tyrosine and Phenylalanine Binding Sites


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase From Mycobacterium Tuberculosis with D-Tyrosine Bound in the Tyrosine and Phenylalanine Binding Sites within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl506

b:61.0
occ:1.00
 NH2 B:ARG100 3.5 38.2 1.0
O B:HOH616 3.6 29.3 1.0
NH1 B:ARG100 3.9 40.5 1.0
CZ B:ARG100 4.2 37.7 1.0
CB B:PRO97 4.4 19.3 1.0
CA B:PRO97 4.9 19.1 1.0
CG B:PRO97 5.0 19.6 1.0

Reference:

S.Reichau, N.J.Blackmore, W.Jiao, E.J.Parker. Probing the Sophisticated Synergistic Allosteric Regulation of Aromatic Amino Acid Biosynthesis in Mycobacterium Tuberculosis Using -Amino Acids. Plos One V. 11 52723 2016.
ISSN: ESSN 1932-6203
PubMed: 27128682
DOI: 10.1371/JOURNAL.PONE.0152723
Page generated: Sat Dec 12 11:40:21 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy