Chlorine in PDB 5e8d: Crystal Structure of Human Epiregulin in Complex with the Fab Fragment of Murine Monoclonal Antibody 9E5

The structure of Crystal Structure of Human Epiregulin in Complex with the Fab Fragment of Murine Monoclonal Antibody 9E5, PDB code: 5e8d was solved by Y.Kado, E.Mizohata, S.Nagatoishi, M.Iijima, K.Shinoda, T.Miyafusa, T.Nakayama, T.Yoshizumi, A.Sugiyama, T.Kawamura, Y.H.Lee, H.Matsumura, H.Doi, H.Fujitani, T.Kodama, Y.Shibasaki, K.Tsumoto, T.Inoue, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	14.91 / 2.50
Space group	I 2 2 2
Cell size a, b, c (Å), α, β, γ (°)	68.602, 100.291, 187.369, 90.00, 90.00, 90.00
R / Rfree (%)	19 / 26.3

The binding sites of Chlorine atom in the Crystal Structure of Human Epiregulin in Complex with the Fab Fragment of Murine Monoclonal Antibody 9E5 (pdb code 5e8d). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Human Epiregulin in Complex with the Fab Fragment of Murine Monoclonal Antibody 9E5, PDB code: 5e8d:

Chlorine binding site 1 out of 1 in the Crystal Structure of Human Epiregulin in Complex with the Fab Fragment of Murine Monoclonal Antibody 9E5


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Epiregulin in Complex with the Fab Fragment of Murine Monoclonal Antibody 9E5 within 5.0Å range: probe atom residue distance (Å) B Occ H:Cl301 b:76.4 occ:1.00 N H:LEU175 3.7 55.3 1.0 CA H:VAL174 4.0 47.5 1.0 CB H:LEU175 4.3 45.4 1.0 C H:VAL174 4.4 56.2 1.0 CB H:VAL174 4.4 48.2 1.0 O H:ALA173 4.6 59.5 1.0 CA H:LEU175 4.6 48.5 1.0 CG H:LEU175 4.8 57.4 1.0

Y.Kado, E.Mizohata, S.Nagatoishi, M.Iijima, K.Shinoda, T.Miyafusa, T.Nakayama, T.Yoshizumi, A.Sugiyama, T.Kawamura, Y.H.Lee, H.Matsumura, H.Doi, H.Fujitani, T.Kodama, Y.Shibasaki, K.Tsumoto, T.Inoue. Epiregulin Recognition Mechanisms By Anti-Epiregulin Antibody 9E5: Structural, Functional, and Molecular Dynamics Simulation Analyses J.Biol.Chem. V. 291 2319 2016.
ISSN: ESSN 1083-351X
PubMed: 26627827
DOI: 10.1074/JBC.M115.656009