Chlorine in PDB 5e9b: Crystal Structure of Human Heparanase in Complex with Hepmer M09S05A

All present enzymatic activity of Crystal Structure of Human Heparanase in Complex with Hepmer M09S05A:
3.2.1.166;

The structure of Crystal Structure of Human Heparanase in Complex with Hepmer M09S05A, PDB code: 5e9b was solved by L.Wu, G.J.Davies, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	52.52 / 1.88
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	45.990, 71.060, 78.290, 90.00, 95.09, 90.00
R / Rfree (%)	17.5 / 21.5

The binding sites of Chlorine atom in the Crystal Structure of Human Heparanase in Complex with Hepmer M09S05A (pdb code 5e9b). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Human Heparanase in Complex with Hepmer M09S05A, PDB code: 5e9b:

Chlorine binding site 1 out of 1 in the Crystal Structure of Human Heparanase in Complex with Hepmer M09S05A


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Heparanase in Complex with Hepmer M09S05A within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl604 b:66.5 occ:1.00 OD1 A:ASN439 3.4 39.6 1.0 N A:THR416 3.5 35.1 1.0 CA A:GLY415 3.7 35.3 1.0 O A:HOH836 3.7 37.2 1.0 OG1 A:THR416 3.7 33.9 1.0 N A:THR440 3.8 43.5 1.0 O A:HOH826 3.8 37.4 1.0 CA A:ASN439 3.8 37.1 1.0 CG2 A:THR416 4.0 32.3 1.0 OG1 A:THR440 4.0 53.1 1.0 CG A:ASN439 4.1 36.9 1.0 C A:GLY415 4.1 37.4 1.0 C A:ASN439 4.3 35.3 1.0 CB A:THR416 4.3 34.5 1.0 CB A:ASN439 4.4 34.4 1.0 CA A:THR416 4.6 35.5 1.0 O A:THR438 4.6 35.3 1.0 N A:ASN439 4.9 32.9 1.0 N A:GLY415 4.9 32.5 1.0 CA A:THR440 4.9 50.2 1.0 ND2 A:ASN439 5.0 38.9 1.0

L.Wu, C.M.Viola, A.M.Brzozowski, G.J.Davies. Structural Characterization of Human Heparanase Reveals Insights Into Substrate Recognition. Nat.Struct.Mol.Biol. V. 22 1016 2015.
ISSN: ESSN 1545-9985
PubMed: 26575439
DOI: 10.1038/NSMB.3136