Chlorine in PDB 5e9c: Crystal Structure of Human Heparanase in Complex with Heparin Tetrasaccharide DP4

All present enzymatic activity of Crystal Structure of Human Heparanase in Complex with Heparin Tetrasaccharide DP4:
3.2.1.166;

The structure of Crystal Structure of Human Heparanase in Complex with Heparin Tetrasaccharide DP4, PDB code: 5e9c was solved by L.Wu, G.J.Davies, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	78.27 / 1.73
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	46.220, 71.120, 78.600, 90.00, 95.23, 90.00
R / Rfree (%)	17.2 / 21.1

The binding sites of Chlorine atom in the Crystal Structure of Human Heparanase in Complex with Heparin Tetrasaccharide DP4 (pdb code 5e9c). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Human Heparanase in Complex with Heparin Tetrasaccharide DP4, PDB code: 5e9c:

Chlorine binding site 1 out of 1 in the Crystal Structure of Human Heparanase in Complex with Heparin Tetrasaccharide DP4


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Heparanase in Complex with Heparin Tetrasaccharide DP4 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl604 b:67.8 occ:1.00 O A:HOH878 3.6 56.1 1.0 CG A:LYS430 4.0 29.1 1.0 CB A:ARG429 4.1 53.2 1.0 CD A:LYS430 4.1 33.2 1.0 CE A:LYS430 4.1 44.9 1.0 CG A:LYS427 4.3 94.4 1.0 O A:HOH879 4.3 52.8 1.0 N A:LYS430 4.3 23.1 1.0 O A:HOH892 4.4 65.1 1.0 CB A:LYS430 4.5 25.6 1.0 CD A:LYS427 4.7 93.4 1.0 NE2 A:HIS458 4.8 30.8 1.0 CA A:ARG429 4.9 43.3 1.0 N A:ARG429 4.9 52.1 1.0 O A:HOH886 4.9 60.4 1.0 CD A:ARG429 5.0 78.4 1.0

L.Wu, C.M.Viola, A.M.Brzozowski, G.J.Davies. Structural Characterization of Human Heparanase Reveals Insights Into Substrate Recognition. Nat.Struct.Mol.Biol. V. 22 1016 2015.
ISSN: ESSN 1545-9985
PubMed: 26575439
DOI: 10.1038/NSMB.3136