Chlorine in PDB 5ehc: Co-Crystal Structure of EIF4E with Nucleotide Mimetic Inhibitor.

The structure of Co-Crystal Structure of EIF4E with Nucleotide Mimetic Inhibitor., PDB code: 5ehc was solved by M.W.Nowicki, M.D.Walkinshaw, P.M.Fischer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	28.35 / 2.40
Space group	P 21 2 21
Cell size a, b, c (Å), α, β, γ (°)	38.489, 52.177, 125.698, 90.00, 90.00, 90.00
R / Rfree (%)	21.8 / 26.4

The binding sites of Chlorine atom in the Co-Crystal Structure of EIF4E with Nucleotide Mimetic Inhibitor. (pdb code 5ehc). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Co-Crystal Structure of EIF4E with Nucleotide Mimetic Inhibitor., PDB code: 5ehc:

Chlorine binding site 1 out of 1 in the Co-Crystal Structure of EIF4E with Nucleotide Mimetic Inhibitor.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Co-Crystal Structure of EIF4E with Nucleotide Mimetic Inhibitor. within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl301 b:60.0 occ:1.00 CL A:5NX301 0.0 60.0 1.0 CAU A:5NX301 1.7 38.4 1.0 CAL A:5NX301 2.7 34.1 1.0 CAJ A:5NX301 2.7 27.1 1.0 CG2 A:THR203 3.2 23.3 1.0 N A:ALA204 3.6 19.4 1.0 CB A:THR203 3.6 26.5 1.0 C A:THR203 3.8 25.8 1.0 CA A:ALA204 4.0 27.0 1.0 CAV A:5NX301 4.0 30.0 1.0 CAI A:5NX301 4.0 26.1 1.0 CB A:ALA204 4.0 23.3 1.0 O A:THR203 4.1 26.9 1.0 O A:HIS200 4.3 21.7 1.0 CA A:THR203 4.4 27.9 1.0 CAK A:5NX301 4.5 31.4 1.0 CD1 A:TRP102 4.5 22.4 1.0 O A:HOH469 4.5 32.4 1.0 NE1 A:TRP102 4.6 20.1 1.0 OG1 A:THR203 4.8 24.0 1.0

F.Soukarieh, M.W.Nowicki, A.Bastide, T.Poyry, C.Jones, K.Dudek, G.Patwardhan, F.Meullenet, N.J.Oldham, M.D.Walkinshaw, A.E.Willis, P.M.Fischer. Design of Nucleotide-Mimetic and Non-Nucleotide Inhibitors of the Translation Initiation Factor EIF4E: Synthesis, Structural and Functional Characterisation. Eur.J.Med.Chem. V. 124 200 2016.
ISSN: ISSN 0223-5234
PubMed: 27592390
DOI: 10.1016/J.EJMECH.2016.08.047