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Chlorine in PDB 5eqb: Crystal Structure of Lanosterol 14-Alpha Demethylase with Intact Transmembrane Domain Bound to Itraconazole
Enzymatic activity of Crystal Structure of Lanosterol 14-Alpha Demethylase with Intact Transmembrane Domain Bound to Itraconazole
All present enzymatic activity of Crystal Structure of Lanosterol 14-Alpha Demethylase with Intact Transmembrane Domain Bound to Itraconazole:
1.14.13.70;
1.14.13.70;
Protein crystallography data
The structure of Crystal Structure of Lanosterol 14-Alpha Demethylase with Intact Transmembrane Domain Bound to Itraconazole, PDB code: 5eqb
was solved by
B.C.Monk,
T.M.Tomasiak,
M.V.Keniya,
F.U.Huschmann,
J.D.A.Tyndall,
J.D.O'connell Iii,
R.D.Cannon,
J.Finer-Morre,
R.M.Stroud,
Center Forstructures Of Membrane Proteins (Csmp),
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 29.88 / 2.19 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 79.630, 67.845, 80.705, 90.00, 99.75, 90.00 |
| R / Rfree (%) | 19.2 / 22.8 |
Other elements in 5eqb:
The structure of Crystal Structure of Lanosterol 14-Alpha Demethylase with Intact Transmembrane Domain Bound to Itraconazole also contains other interesting chemical elements:
| Iron | (Fe) | 1 atom |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Lanosterol 14-Alpha Demethylase with Intact Transmembrane Domain Bound to Itraconazole
(pdb code 5eqb). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Lanosterol 14-Alpha Demethylase with Intact Transmembrane Domain Bound to Itraconazole, PDB code: 5eqb:
Jump to Chlorine binding site number: 1; 2;
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Lanosterol 14-Alpha Demethylase with Intact Transmembrane Domain Bound to Itraconazole, PDB code: 5eqb:
Jump to Chlorine binding site number: 1; 2;
Chlorine binding site 1 out of 2 in 5eqb
Go back to
Chlorine Binding Sites List in 5eqb
Chlorine binding site 1 out
of 2 in the Crystal Structure of Lanosterol 14-Alpha Demethylase with Intact Transmembrane Domain Bound to Itraconazole
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of Lanosterol 14-Alpha Demethylase with Intact Transmembrane Domain Bound to Itraconazole within 5.0Å range:
|
Chlorine binding site 2 out of 2 in 5eqb
Go back to
Chlorine Binding Sites List in 5eqb
Chlorine binding site 2 out
of 2 in the Crystal Structure of Lanosterol 14-Alpha Demethylase with Intact Transmembrane Domain Bound to Itraconazole
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Crystal Structure of Lanosterol 14-Alpha Demethylase with Intact Transmembrane Domain Bound to Itraconazole within 5.0Å range:
|
Reference:
B.C.Monk,
T.M.Tomasiak,
M.V.Keniya,
F.U.Huschmann,
J.D.Tyndall,
J.D.O'connell,
R.D.Cannon,
J.G.Mcdonald,
A.Rodriguez,
J.S.Finer-Moore,
R.M.Stroud.
Architecture of A Single Membrane Spanning Cytochrome P450 Suggests Constraints That Orient the Catalytic Domain Relative to A Bilayer. Proc.Natl.Acad.Sci.Usa V. 111 3865 2014.
ISSN: ESSN 1091-6490
PubMed: 24613931
DOI: 10.1073/PNAS.1324245111
Page generated: Fri Jul 26 07:27:14 2024
ISSN: ESSN 1091-6490
PubMed: 24613931
DOI: 10.1073/PNAS.1324245111
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