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Chlorine in PDB 5ex4: 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase From Mycobacterium Tuberculosis Complexed with Tryptophan in All Three Allosteric Binding Sites

Enzymatic activity of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase From Mycobacterium Tuberculosis Complexed with Tryptophan in All Three Allosteric Binding Sites

All present enzymatic activity of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase From Mycobacterium Tuberculosis Complexed with Tryptophan in All Three Allosteric Binding Sites:
2.5.1.54;

Protein crystallography data

The structure of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase From Mycobacterium Tuberculosis Complexed with Tryptophan in All Three Allosteric Binding Sites, PDB code: 5ex4 was solved by S.Reichau, W.Jiao, N.J.Blackmore, R.D.Hutton, E.J.Parker, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 44.24 / 2.25
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 204.680, 204.680, 66.740, 90.00, 90.00, 120.00
R / Rfree (%) 14.1 / 17

Other elements in 5ex4:

The structure of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase From Mycobacterium Tuberculosis Complexed with Tryptophan in All Three Allosteric Binding Sites also contains other interesting chemical elements:

Manganese (Mn) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase From Mycobacterium Tuberculosis Complexed with Tryptophan in All Three Allosteric Binding Sites (pdb code 5ex4). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase From Mycobacterium Tuberculosis Complexed with Tryptophan in All Three Allosteric Binding Sites, PDB code: 5ex4:

Chlorine binding site 1 out of 1 in 5ex4

Go back to Chlorine Binding Sites List in 5ex4
Chlorine binding site 1 out of 1 in the 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase From Mycobacterium Tuberculosis Complexed with Tryptophan in All Three Allosteric Binding Sites


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase From Mycobacterium Tuberculosis Complexed with Tryptophan in All Three Allosteric Binding Sites within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl509

b:39.8
occ:1.00
 O B:HOH845 2.8 23.0 1.0
NH1 B:ARG23 3.1 28.8 1.0
N B:LEU18 3.2 23.4 1.0
CD B:ARG23 3.5 28.1 1.0
CA B:PRO17 3.7 43.1 1.0
CD1 B:TRP508 3.9 39.6 1.0
CB B:LEU18 3.9 22.7 1.0
C B:PRO17 4.0 30.6 1.0
NE1 B:TRP508 4.0 40.3 1.0
CG B:LEU18 4.1 28.4 1.0
CZ B:ARG23 4.1 27.2 1.0
CA B:LEU18 4.1 27.2 1.0
NE B:ARG23 4.2 29.7 1.0
CB B:PRO17 4.2 42.7 1.0
CG B:ARG23 4.5 22.4 1.0
O B:LEU18 4.6 26.6 1.0
CD1 B:LEU18 4.6 25.0 1.0
CB B:ARG23 4.6 19.2 1.0
O B:PRO16 4.8 35.9 1.0
C B:LEU18 4.9 26.7 1.0
CG B:TRP508 4.9 39.8 1.0

Reference:

S.Reichau, N.J.Blackmore, W.Jiao, E.J.Parker. 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase From Mycobacterium Tuberculosis Complexed with Tryptophan in All Three Allosteric Binding Sites To Be Published.
Page generated: Fri Jul 26 07:33:19 2024

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