Chlorine in PDB 5faf: N184K Pathological Variant of Gelsolin Domain 2 (Orthorhombic Form)

The structure of N184K Pathological Variant of Gelsolin Domain 2 (Orthorhombic Form), PDB code: 5faf was solved by F.Boni, M.Milani, S.Ricagno, M.Bolognesi, M.De Rosa, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	42.50 / 1.05
Space group	P 2 21 21
Cell size a, b, c (Å), α, β, γ (°)	26.390, 50.120, 80.180, 90.00, 90.00, 90.00
R / Rfree (%)	13 / 16.8

The structure of N184K Pathological Variant of Gelsolin Domain 2 (Orthorhombic Form) also contains other interesting chemical elements:

Calcium

(Ca)

2 atoms

The binding sites of Chlorine atom in the N184K Pathological Variant of Gelsolin Domain 2 (Orthorhombic Form) (pdb code 5faf). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the N184K Pathological Variant of Gelsolin Domain 2 (Orthorhombic Form), PDB code: 5faf:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the N184K Pathological Variant of Gelsolin Domain 2 (Orthorhombic Form)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of N184K Pathological Variant of Gelsolin Domain 2 (Orthorhombic Form) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl306 b:11.3 occ:0.90 ND1 A:HIS232 2.1 13.4 1.0 CE1 A:HIS232 3.0 14.5 1.0 CG A:HIS232 3.1 11.8 1.0 CB A:HIS232 3.5 11.3 1.0 O A:HOH555 4.1 18.0 1.0 NE2 A:HIS232 4.1 13.7 1.0 CD2 A:HIS232 4.2 13.2 1.0 CA A:HIS232 4.4 11.1 1.0 O A:HOH569 4.4 45.9 1.0 O A:HOH587 4.6 48.5 1.0 O A:HOH486 4.7 28.9 1.0

Chlorine binding site 2 out of 2 in the N184K Pathological Variant of Gelsolin Domain 2 (Orthorhombic Form)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of N184K Pathological Variant of Gelsolin Domain 2 (Orthorhombic Form) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl307 b:15.8 occ:0.80 NE2 A:HIS151 2.1 14.8 1.0 N A:GLY148 2.1 21.9 1.0 O A:HOH526 2.1 18.1 1.0 O A:GLY148 2.3 14.6 1.0 C A:GLY148 3.0 16.4 1.0 CE1 A:HIS151 3.0 15.7 1.0 CA A:GLY148 3.0 23.0 1.0 CD2 A:HIS151 3.2 14.3 1.0 O A:HOH425 3.2 43.2 0.5 ND1 A:HIS151 4.1 16.3 1.0 CG A:HIS151 4.2 13.8 1.0 N A:SER149 4.2 16.9 1.0 O A:HOH556 4.6 64.5 1.0 CA A:SER149 5.0 15.4 0.4

F.Boni, M.Milani, R.Porcari, A.Barbiroli, S.Ricagno, M.De Rosa. Molecular Basis of A Novel Renal Amyloidosis Due to N184K Gelsolin Variant. Sci Rep V. 6 33463 2016.
ISSN: ESSN 2045-2322
PubMed: 27633054
DOI: 10.1038/SREP33463