Atomistry » Chlorine » PDB 5f63-5fdd » 5fat
Atomistry »
  Chlorine »
    PDB 5f63-5fdd »
      5fat »

Chlorine in PDB 5fat: Oxa-48 in Complex with Fpi-1602

Enzymatic activity of Oxa-48 in Complex with Fpi-1602

All present enzymatic activity of Oxa-48 in Complex with Fpi-1602:
3.5.2.6;

Protein crystallography data

The structure of Oxa-48 in Complex with Fpi-1602, PDB code: 5fat was solved by A.M.King, D.T.King, S.French, E.Brouillette, A.Asli, A.N.Alexander, M.Vuckovic, S.N.Maiti, T.R.Parr, E.D.Brown, F.Malouin, N.C.J.Strynadka, G.D.Wright, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.18 / 2.09
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 73.110, 75.750, 106.650, 90.00, 90.00, 90.00
R / Rfree (%) 16.7 / 21.6

Other elements in 5fat:

The structure of Oxa-48 in Complex with Fpi-1602 also contains other interesting chemical elements:

Cadmium (Cd) 2 atoms
Cobalt (Co) 8 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Oxa-48 in Complex with Fpi-1602 (pdb code 5fat). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Oxa-48 in Complex with Fpi-1602, PDB code: 5fat:

Chlorine binding site 1 out of 1 in 5fat

Go back to Chlorine Binding Sites List in 5fat
Chlorine binding site 1 out of 1 in the Oxa-48 in Complex with Fpi-1602


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Oxa-48 in Complex with Fpi-1602 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl302

b:26.4
occ:1.00
NH1 B:ARG206 3.1 25.0 1.0
NH1 A:ARG206 3.2 26.2 1.0
NH2 B:ARG206 3.2 26.5 1.0
NH2 A:ARG206 3.2 25.7 1.0
O B:HOH493 3.2 34.7 1.0
CZ B:ARG206 3.6 26.1 1.0
CZ A:ARG206 3.6 23.9 1.0
CD2 B:LEU196 4.1 23.8 1.0
CD2 A:LEU196 4.3 23.2 1.0
CA A:GLN193 4.3 22.7 1.0
CG B:GLN193 4.4 24.2 1.0
CA B:GLN193 4.4 22.5 1.0
CG A:GLN193 4.5 23.4 1.0
CB A:GLN193 4.5 21.6 1.0
CB B:GLN193 4.5 22.8 1.0
CB B:LEU196 4.9 22.7 1.0
CB A:LEU196 4.9 20.8 1.0
NE B:ARG206 4.9 23.1 1.0
NE A:ARG206 4.9 22.8 1.0
CG B:LEU196 4.9 23.1 1.0
O A:GLN193 4.9 22.1 1.0
CG A:LEU196 5.0 20.8 1.0

Reference:

A.M.King, D.T.King, S.French, E.Brouillette, A.Asli, J.A.Alexander, M.Vuckovic, S.N.Maiti, T.R.Parr, E.D.Brown, F.Malouin, N.C.Strynadka, G.D.Wright. Structural and Kinetic Characterization of Diazabicyclooctanes As Dual Inhibitors of Both Serine-Beta-Lactamases and Penicillin-Binding Proteins. Acs Chem.Biol. V. 11 864 2016.
ISSN: ESSN 1554-8937
PubMed: 26731698
DOI: 10.1021/ACSCHEMBIO.5B00944
Page generated: Sat Dec 12 11:43:24 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy