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Chlorine in PDB 5fcp: X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and Cisplatin at Long Incubation Times

Enzymatic activity of X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and Cisplatin at Long Incubation Times

All present enzymatic activity of X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and Cisplatin at Long Incubation Times:
3.2.1.17;

Protein crystallography data

The structure of X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and Cisplatin at Long Incubation Times, PDB code: 5fcp was solved by I.Russo Krauss, G.Ferraro, A.Pica, A.Merlino, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 56.06 / 1.55
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 79.280, 79.280, 37.450, 90.00, 90.00, 90.00
R / Rfree (%) 16.8 / 21.3

Other elements in 5fcp:

The structure of X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and Cisplatin at Long Incubation Times also contains other interesting chemical elements:

Platinum (Pt) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and Cisplatin at Long Incubation Times (pdb code 5fcp). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and Cisplatin at Long Incubation Times, PDB code: 5fcp:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in 5fcp

Go back to Chlorine Binding Sites List in 5fcp
Chlorine binding site 1 out of 3 in the X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and Cisplatin at Long Incubation Times


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and Cisplatin at Long Incubation Times within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl203

b:41.5
occ:0.50
 CL2 A:CPT203 0.0 41.5 0.5
PT1 A:CPT203 2.3 52.1 0.5
N2 A:CPT203 3.2 43.7 0.5
ND1 A:HIS15 3.2 47.0 1.0
OD1 A:ASN93 3.3 44.2 1.0
CB A:HIS15 3.8 30.5 1.0
CG A:ASN93 3.8 33.7 1.0
CG A:HIS15 3.8 33.9 1.0
CG1 A:VAL92 3.8 21.1 1.0
CG2 A:THR89 3.8 30.7 1.0
ND2 A:ASN93 3.9 38.6 1.0
O A:HIS15 4.0 28.7 1.0
O A:THR89 4.1 21.3 1.0
CB A:VAL92 4.1 18.9 1.0
CE1 A:HIS15 4.2 39.0 1.0
N1 A:CPT203 4.3 41.4 0.5
CA A:THR89 4.3 21.0 1.0
O A:HOH352 4.4 48.6 1.0
CA A:HIS15 4.4 26.1 1.0
NZ A:LYS96 4.5 27.7 1.0
N A:ASN93 4.6 20.5 1.0
CB A:THR89 4.6 24.9 1.0
C A:THR89 4.6 21.8 1.0
C A:HIS15 4.7 24.0 1.0
OG1 A:THR89 4.7 26.3 1.0
CB A:ASN93 4.9 23.9 1.0
CD2 A:HIS15 4.9 36.0 1.0

Chlorine binding site 2 out of 3 in 5fcp

Go back to Chlorine Binding Sites List in 5fcp
Chlorine binding site 2 out of 3 in the X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and Cisplatin at Long Incubation Times


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and Cisplatin at Long Incubation Times within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl204

b:45.1
occ:0.50
 CL2 A:CPT204 0.0 45.1 0.5
O A:HOH382 1.5 19.9 0.5
PT1 A:CPT204 2.2 48.2 0.5
N1 A:CPT204 3.0 55.9 0.5
O A:HOH360 3.1 30.2 0.5
O A:HOH323 3.2 40.2 0.5
NE2 A:HIS15 3.3 40.6 1.0
O A:HOH397 3.4 51.6 1.0
N A:ILE88 3.5 22.6 1.0
OD1 A:ASP87 3.5 29.4 1.0
CG1 A:ILE88 3.8 22.5 1.0
CA A:ASP87 4.0 24.3 1.0
CE1 A:HIS15 4.2 39.0 1.0
C A:ASP87 4.2 21.5 1.0
CD2 A:HIS15 4.2 36.0 1.0
CG A:ASP87 4.3 30.7 1.0
NH1 A:ARG14 4.3 58.4 1.0
CA A:ILE88 4.5 18.9 1.0
O A:SER86 4.5 25.9 1.0
CB A:ILE88 4.6 19.4 1.0
CB A:ASP87 4.7 26.9 1.0
N A:THR89 4.7 20.9 1.0
OG1 A:THR89 4.8 26.3 1.0
CD1 A:ILE88 4.8 23.3 1.0
C A:ILE88 4.9 19.7 1.0
CB A:ALA11 4.9 20.5 1.0
CG2 A:ILE88 5.0 20.3 1.0

Chlorine binding site 3 out of 3 in 5fcp

Go back to Chlorine Binding Sites List in 5fcp
Chlorine binding site 3 out of 3 in the X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and Cisplatin at Long Incubation Times


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and Cisplatin at Long Incubation Times within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl205

b:20.8
occ:1.00
 OH A:TYR23 3.1 15.0 1.0
O A:HOH349 3.4 23.1 1.0
CZ A:TYR23 3.7 14.2 1.0
CE2 A:TYR23 3.7 12.5 1.0
CA A:GLY104 4.1 16.0 1.0
O A:ARG21 4.5 19.9 1.0
N A:GLY104 4.7 14.7 1.0
O A:HOH393 4.8 50.8 1.0
O A:HOH325 4.8 26.8 1.0
CE1 A:TYR23 4.9 13.7 1.0
CD2 A:TYR23 5.0 13.0 1.0

Reference:

G.Ferraro, A.Pica, I.Russo Krauss, F.Pane, A.Amoresano, A.Merlino. Effect of Temperature on the Interaction of Cisplatin with the Model Protein Hen Egg White Lysozyme. J.Biol.Inorg.Chem. V. 21 433 2016.
ISSN: ESSN 1432-1327
PubMed: 27040953
DOI: 10.1007/S00775-016-1352-0
Page generated: Fri Jul 26 07:46:10 2024

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