Chlorine in PDB 5fma: Human Notch 1, Egf 4-7

The structure of Human Notch 1, Egf 4-7, PDB code: 5fma was solved by P.C.Weisshuhn, D.Sheppard, P.Taylor, P.Whiteman, S.M.Lea, P.A.Handford, C.Redfield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.42 / 2.46
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	40.940, 86.830, 53.450, 90.00, 107.58, 90.00
R / Rfree (%)	25.9 / 26.3

The structure of Human Notch 1, Egf 4-7 also contains other interesting chemical elements:

Calcium

(Ca)

5 atoms

The binding sites of Chlorine atom in the Human Notch 1, Egf 4-7 (pdb code 5fma). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Human Notch 1, Egf 4-7, PDB code: 5fma:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Human Notch 1, Egf 4-7


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Notch 1, Egf 4-7 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1297 b:89.4 occ:1.00 O B:ARG282 3.3 61.5 1.0 NH2 B:ARG282 3.9 78.8 1.0 NE B:ARG282 4.2 76.9 1.0 N B:PRO284 4.2 57.1 1.0 C B:CYS283 4.2 62.3 1.0 O B:GLY269 4.2 63.3 1.0 CZ B:ARG282 4.2 92.1 1.0 C B:ARG282 4.3 63.8 1.0 CA B:PRO284 4.4 55.8 1.0 O B:CYS283 4.4 61.7 1.0 CB B:ALA271 4.4 64.3 1.0 N B:ALA271 4.5 64.5 1.0 CG B:PRO284 4.6 61.6 1.0 CD B:PRO284 4.7 58.4 1.0 CB B:PRO284 4.8 56.9 1.0 CG B:ARG282 4.8 67.8 1.0 CA B:CYS283 4.9 60.9 1.0 CB B:ARG282 5.0 60.5 1.0

Chlorine binding site 2 out of 2 in the Human Notch 1, Egf 4-7


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Human Notch 1, Egf 4-7 within 5.0Å range:

P.C.Weisshuhn, D.Sheppard, P.Taylor, P.Whiteman, S.M.Lea, P.A.Handford, C.Redfield. Non-Linear and Flexible Regions of the Human NOTCH1 Extracellular Domain Revealed By High-Resolution Structural Studies. Structure V. 24 555 2016.
ISSN: ISSN 0969-2126
PubMed: 26996961
DOI: 10.1016/J.STR.2016.02.010