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Chlorine in PDB 5fom: Crystal Structure of the Cryptosporidium Muris Cytosolic Leucyl-Trna Synthetase Editing Domain Complex with the Adduct Amp-AN6426

Enzymatic activity of Crystal Structure of the Cryptosporidium Muris Cytosolic Leucyl-Trna Synthetase Editing Domain Complex with the Adduct Amp-AN6426

All present enzymatic activity of Crystal Structure of the Cryptosporidium Muris Cytosolic Leucyl-Trna Synthetase Editing Domain Complex with the Adduct Amp-AN6426:
6.1.1.4;

Protein crystallography data

The structure of Crystal Structure of the Cryptosporidium Muris Cytosolic Leucyl-Trna Synthetase Editing Domain Complex with the Adduct Amp-AN6426, PDB code: 5fom was solved by A.Palencia, R.J.Liu, M.Lukarska, J.Gut, A.Bougdour, B.Touquet, E.D.Wang, M.R.K.Alley, P.J.Rosenthal, M.A.Hakimi, S.Cusack, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 60.64 / 2.10
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 65.065, 65.065, 167.301, 90.00, 90.00, 90.00
R / Rfree (%) 19.9 / 23.9

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of the Cryptosporidium Muris Cytosolic Leucyl-Trna Synthetase Editing Domain Complex with the Adduct Amp-AN6426 (pdb code 5fom). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of the Cryptosporidium Muris Cytosolic Leucyl-Trna Synthetase Editing Domain Complex with the Adduct Amp-AN6426, PDB code: 5fom:

Chlorine binding site 1 out of 1 in 5fom

Go back to Chlorine Binding Sites List in 5fom
Chlorine binding site 1 out of 1 in the Crystal Structure of the Cryptosporidium Muris Cytosolic Leucyl-Trna Synthetase Editing Domain Complex with the Adduct Amp-AN6426


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Cryptosporidium Muris Cytosolic Leucyl-Trna Synthetase Editing Domain Complex with the Adduct Amp-AN6426 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1542

b:53.9
occ:1.00
 CL A:A2H1542 0.0 53.9 1.0
C13 A:A2H1542 1.8 52.3 1.0
C14 A:A2H1542 2.8 52.3 1.0
C11 A:A2H1542 2.8 49.2 1.0
C10 A:A2H1542 3.3 47.4 1.0
C17 A:A2H1542 3.5 45.7 1.0
OG1 A:THR292 3.6 41.4 1.0
CB A:VAL426 3.7 41.4 1.0
CG2 A:THR292 3.7 42.9 1.0
CB A:SER430 3.8 53.3 1.0
CB A:THR292 3.8 41.8 1.0
O A:ASP429 3.8 55.1 1.0
C A:ASP429 4.0 51.1 1.0
NH1 A:ARG289 4.0 47.3 1.0
C15 A:A2H1542 4.1 53.1 1.0
C12 A:A2H1542 4.1 50.5 1.0
CG1 A:VAL426 4.1 44.5 1.0
N A:SER430 4.1 47.5 1.0
CG2 A:VAL426 4.2 44.5 1.0
O A:VAL426 4.2 41.4 1.0
CD A:ARG289 4.3 46.6 1.0
CA A:SER430 4.3 52.0 1.0
N18 A:A2H1542 4.4 45.3 1.0
CB A:ASP429 4.5 54.8 1.0
CB A:ARG289 4.6 42.6 1.0
CZ A:ARG289 4.6 47.8 1.0
O1 A:A2H1542 4.6 46.4 1.0
C16 A:A2H1542 4.6 54.9 1.0
OD2 A:ASP433 4.7 50.4 1.0
NE A:ARG289 4.7 47.6 1.0
CA A:ASP429 4.8 51.3 1.0
CA A:VAL426 4.8 42.2 1.0
OG A:SER430 4.8 56.3 1.0
CG A:ARG289 4.9 43.7 1.0
C A:VAL426 5.0 43.6 1.0

Reference:

A.Palencia, R.Liu, M.Lukarska, J.Gut, A.Bougdour, B.Touquet, E.Wang, X.Li, M.R.K.Alley, Y.R.Freund, P.J.Rosenthal, M.Hakimi, S.Cusack. Cryptosporidium and Toxoplasma Parasites Are Inhibited By A Benzoxaborole Targeting Leucyl-Trna Synthetase. Antimicrob.Agents Chemother. V. 60 5817 2016.
ISSN: ISSN 0066-4804
PubMed: 27431220
DOI: 10.1128/AAC.00873-16
Page generated: Fri Jul 26 08:06:23 2024

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