Chlorine in PDB 5got: Crystal Structure of Sp-Ptp, Low Molecular Weight Protein Tyrosine Phosphatase From Streptococcus Pyogenes

All present enzymatic activity of Crystal Structure of Sp-Ptp, Low Molecular Weight Protein Tyrosine Phosphatase From Streptococcus Pyogenes:
3.1.3.48;

The structure of Crystal Structure of Sp-Ptp, Low Molecular Weight Protein Tyrosine Phosphatase From Streptococcus Pyogenes, PDB code: 5got was solved by B.Ku, C.W.Keum, S.J.Kiim, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	32.95 / 1.90
Space group	P 61 2 2
Cell size a, b, c (Å), α, β, γ (°)	58.003, 58.003, 218.229, 90.00, 90.00, 120.00
R / Rfree (%)	19.6 / 23.8

The binding sites of Chlorine atom in the Crystal Structure of Sp-Ptp, Low Molecular Weight Protein Tyrosine Phosphatase From Streptococcus Pyogenes (pdb code 5got). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Crystal Structure of Sp-Ptp, Low Molecular Weight Protein Tyrosine Phosphatase From Streptococcus Pyogenes, PDB code: 5got:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in the Crystal Structure of Sp-Ptp, Low Molecular Weight Protein Tyrosine Phosphatase From Streptococcus Pyogenes


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Sp-Ptp, Low Molecular Weight Protein Tyrosine Phosphatase From Streptococcus Pyogenes within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl201 b:28.6 occ:1.00 O A:HOH403 2.3 19.5 1.0 N A:GLY10 3.4 23.9 1.0 O A:HOH305 3.4 25.4 1.0 CA A:GLY10 3.7 22.4 1.0 O A:HOH328 3.7 23.6 1.0 O A:HOH314 4.1 31.1 1.0 CB A:LEU9 4.2 22.1 1.0 CD2 A:LEU9 4.3 25.2 1.0 C A:LEU9 4.4 28.6 1.0 O A:HOH339 4.4 21.9 1.0 CG A:LEU9 4.5 26.1 1.0 C A:GLY10 4.5 24.2 1.0 CA A:LEU9 4.7 23.7 1.0 CG1 A:ILE12 4.7 24.3 1.0 N A:ASN11 4.8 21.6 1.0 N A:LEU9 4.8 21.8 1.0 CE3 A:TRP117 4.9 30.6 1.0 SG A:CYS8 5.0 20.8 1.0

Chlorine binding site 2 out of 3 in the Crystal Structure of Sp-Ptp, Low Molecular Weight Protein Tyrosine Phosphatase From Streptococcus Pyogenes


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Sp-Ptp, Low Molecular Weight Protein Tyrosine Phosphatase From Streptococcus Pyogenes within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl202 b:32.5 occ:1.00 CB A:SER87 3.7 30.8 1.0 CG1 A:VAL90 3.7 26.2 1.0 CA A:SER87 3.8 28.7 1.0 CB A:VAL90 3.8 23.9 1.0 CG2 A:VAL90 4.2 19.7 1.0 CD2 A:LEU107 4.3 25.1 1.0 O A:SER87 4.4 31.4 1.0 CB A:LEU107 4.5 20.7 1.0 CD1 A:LEU107 4.5 19.4 1.0 O A:HOH343 4.6 30.9 1.0 C A:SER87 4.7 31.9 1.0 CG A:LEU107 4.7 21.6 1.0 N A:SER87 4.9 25.1 1.0

Chlorine binding site 3 out of 3 in the Crystal Structure of Sp-Ptp, Low Molecular Weight Protein Tyrosine Phosphatase From Streptococcus Pyogenes


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Sp-Ptp, Low Molecular Weight Protein Tyrosine Phosphatase From Streptococcus Pyogenes within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl203 b:57.6 occ:1.00 O A:HOH309 2.6 37.3 1.0 O A:HOH326 2.8 33.9 1.0 O A:HOH377 3.9 40.1 1.0 O A:ARG139 4.1 31.9 1.0 CG A:ARG139 4.2 34.0 1.0 NE A:ARG139 4.5 38.0 1.0 CD2 A:LEU140 4.6 30.3 1.0 CE2 A:TYR81 4.7 28.7 1.0 OH A:TYR106 4.8 27.5 1.0 C A:ARG139 4.9 30.1 1.0 OH A:TYR81 4.9 33.4 1.0

B.Ku, C.W.Keum, H.S.Lee, H.-Y.Yun, H.-C.Shin, B.Y.Kim, S.J.Kim. Crystal Structure of Sp-Ptp, A Low Molecular Weight Protein Tyrosine Phosphatase From Streptococcus Pyogenes Biochem.Biophys.Res.Commun. V. 478 1217 2016.
ISSN: ESSN 1090-2104
PubMed: 27545603
DOI: 10.1016/J.BBRC.2016.08.097