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Chlorine in PDB 5ih5: Human Casein Kinase 1 Isoform Delta (Kinase Domain) in Complex with Epiblastin A

Enzymatic activity of Human Casein Kinase 1 Isoform Delta (Kinase Domain) in Complex with Epiblastin A

All present enzymatic activity of Human Casein Kinase 1 Isoform Delta (Kinase Domain) in Complex with Epiblastin A:
2.7.11.1; 2.7.11.26;

Protein crystallography data

The structure of Human Casein Kinase 1 Isoform Delta (Kinase Domain) in Complex with Epiblastin A, PDB code: 5ih5 was solved by A.Ursu, D.J.Illich, Y.Takemoto, A.T.Porfetye, M.Zhang, A.Brockmeyer, P.Janning, N.Watanabe, H.Osada, I.R.Vetter, S.Ziegler, H.R.Schoeler, H.Waldmann, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 45.21 / 2.25
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 65.070, 65.070, 151.480, 90.00, 90.00, 120.00
R / Rfree (%) 24 / 26

Other elements in 5ih5:

The structure of Human Casein Kinase 1 Isoform Delta (Kinase Domain) in Complex with Epiblastin A also contains other interesting chemical elements:

Zinc (Zn) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Human Casein Kinase 1 Isoform Delta (Kinase Domain) in Complex with Epiblastin A (pdb code 5ih5). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Human Casein Kinase 1 Isoform Delta (Kinase Domain) in Complex with Epiblastin A, PDB code: 5ih5:

Chlorine binding site 1 out of 1 in 5ih5

Go back to Chlorine Binding Sites List in 5ih5
Chlorine binding site 1 out of 1 in the Human Casein Kinase 1 Isoform Delta (Kinase Domain) in Complex with Epiblastin A


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Casein Kinase 1 Isoform Delta (Kinase Domain) in Complex with Epiblastin A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl302

b:0.4
occ:1.00
 CL A:AUE302 0.0 0.4 1.0
C15 A:AUE302 1.8 0.1 1.0
C16 A:AUE302 2.6 0.5 1.0
C14 A:AUE302 3.0 0.7 1.0
CE A:MET80 3.1 85.8 1.0
CG A:MET82 3.3 78.5 1.0
SD A:MET82 3.6 82.1 1.0
CB A:LYS38 3.9 77.7 1.0
CG A:MET80 4.0 80.9 1.0
C11 A:AUE302 4.0 98.4 1.0
CD A:LYS38 4.2 87.0 1.0
SD A:MET80 4.2 86.2 1.0
C13 A:AUE302 4.3 0.5 1.0
O A:MET80 4.3 74.9 1.0
CB A:MET82 4.4 73.3 1.0
N A:LYS38 4.4 73.8 1.0
O A:ALA36 4.5 68.5 1.0
CB A:MET80 4.6 77.8 1.0
C12 A:AUE302 4.7 0.6 1.0
CD1 A:ILE23 4.7 73.1 1.0
N A:MET82 4.7 74.4 1.0
CG A:LYS38 4.7 84.0 1.0
CE A:MET82 4.8 80.2 1.0
CA A:LYS38 4.8 77.7 1.0
N10 A:AUE302 4.9 78.4 1.0
C09 A:AUE302 4.9 89.0 1.0
C A:MET80 4.9 75.3 1.0
C A:ILE37 4.9 72.8 1.0
C A:ALA36 5.0 69.0 1.0
CG2 A:ILE23 5.0 71.1 1.0

Reference:

A.Ursu, D.J.Illich, Y.Takemoto, A.T.Porfetye, M.Zhang, A.Brockmeyer, P.Janning, N.Watanabe, H.Osada, I.R.Vetter, S.Ziegler, H.R.Scholer, H.Waldmann. Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells By Inhibition of Casein Kinase 1. Cell Chem Biol V. 23 494 2016.
ISSN: ESSN 2451-9456
PubMed: 27049670
DOI: 10.1016/J.CHEMBIOL.2016.02.015
Page generated: Fri Jul 26 09:19:47 2024

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