Chlorine in PDB 5is0: Structure of TRPV1 in Complex with Capsazepine, Determined in Lipid Nanodisc

The binding sites of Chlorine atom in the Structure of TRPV1 in Complex with Capsazepine, Determined in Lipid Nanodisc (pdb code 5is0). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Structure of TRPV1 in Complex with Capsazepine, Determined in Lipid Nanodisc, PDB code: 5is0:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in the Structure of TRPV1 in Complex with Capsazepine, Determined in Lipid Nanodisc


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of TRPV1 in Complex with Capsazepine, Determined in Lipid Nanodisc within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl801 b:20.0 occ:1.00 CL2 C:6ET801 0.0 20.0 1.0 C22 C:6ET801 1.8 20.0 1.0 C24 C:6ET801 2.7 20.0 1.0 C21 C:6ET801 2.7 20.0 1.0 H241 C:6ET801 2.8 20.0 1.0 H211 C:6ET801 2.8 20.0 1.0 CD1 C:PHE543 3.1 20.0 1.0 CE1 C:PHE543 3.2 20.0 1.0 CD2 B:LEU662 3.9 20.0 1.0 C20 C:6ET801 4.0 20.0 1.0 C25 C:6ET801 4.0 20.0 1.0 CB B:ALA665 4.1 20.0 1.0 CG C:PHE543 4.4 20.0 1.0 CE1 B:PHE591 4.5 20.0 1.0 C19 C:6ET801 4.5 20.0 1.0 CZ C:PHE543 4.6 20.0 1.0 CG2 B:ILE661 4.6 20.0 1.0 H201 C:6ET801 4.7 20.0 1.0 H251 C:6ET801 4.7 20.0 1.0 CB C:ALA546 5.0 20.0 1.0 CB C:PHE543 5.0 20.0 1.0

Chlorine binding site 2 out of 4 in the Structure of TRPV1 in Complex with Capsazepine, Determined in Lipid Nanodisc


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of TRPV1 in Complex with Capsazepine, Determined in Lipid Nanodisc within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl801 b:20.0 occ:1.00 CL2 B:6ET801 0.0 20.0 1.0 C22 B:6ET801 1.8 20.0 1.0 C24 B:6ET801 2.7 20.0 1.0 C21 B:6ET801 2.7 20.0 1.0 H241 B:6ET801 2.8 20.0 1.0 H211 B:6ET801 2.8 20.0 1.0 CD1 B:PHE543 3.1 20.0 1.0 CE1 B:PHE543 3.2 20.0 1.0 CD2 E:LEU662 3.9 20.0 1.0 C20 B:6ET801 4.0 20.0 1.0 C25 B:6ET801 4.0 20.0 1.0 CB E:ALA665 4.1 20.0 1.0 CG B:PHE543 4.4 20.0 1.0 C19 B:6ET801 4.5 20.0 1.0 CE1 E:PHE591 4.5 20.0 1.0 CZ B:PHE543 4.5 20.0 1.0 CG2 E:ILE661 4.5 20.0 1.0 H201 B:6ET801 4.7 20.0 1.0 H251 B:6ET801 4.7 20.0 1.0 CB B:PHE543 5.0 20.0 1.0

Chlorine binding site 3 out of 4 in the Structure of TRPV1 in Complex with Capsazepine, Determined in Lipid Nanodisc


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Structure of TRPV1 in Complex with Capsazepine, Determined in Lipid Nanodisc within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl801 b:20.0 occ:1.00 CL2 D:6ET801 0.0 20.0 1.0 C22 D:6ET801 1.8 20.0 1.0 C24 D:6ET801 2.7 20.0 1.0 C21 D:6ET801 2.7 20.0 1.0 H241 D:6ET801 2.8 20.0 1.0 H211 D:6ET801 2.8 20.0 1.0 CD1 D:PHE543 3.2 20.0 1.0 CE1 D:PHE543 3.2 20.0 1.0 CD2 C:LEU662 3.9 20.0 1.0 C20 D:6ET801 4.0 20.0 1.0 C25 D:6ET801 4.0 20.0 1.0 CB C:ALA665 4.1 20.0 1.0 CE1 C:PHE591 4.4 20.0 1.0 CG D:PHE543 4.4 20.0 1.0 C19 D:6ET801 4.5 20.0 1.0 CG2 C:ILE661 4.6 20.0 1.0 CZ D:PHE543 4.6 20.0 1.0 H201 D:6ET801 4.7 20.0 1.0 H251 D:6ET801 4.7 20.0 1.0 CZ C:PHE591 5.0 20.0 1.0 CB D:ALA546 5.0 20.0 1.0

Chlorine binding site 4 out of 4 in the Structure of TRPV1 in Complex with Capsazepine, Determined in Lipid Nanodisc


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Structure of TRPV1 in Complex with Capsazepine, Determined in Lipid Nanodisc within 5.0Å range: probe atom residue distance (Å) B Occ E:Cl801 b:20.0 occ:1.00 CL2 E:6ET801 0.0 20.0 1.0 C22 E:6ET801 1.8 20.0 1.0 C24 E:6ET801 2.7 20.0 1.0 C21 E:6ET801 2.7 20.0 1.0 H241 E:6ET801 2.8 20.0 1.0 H211 E:6ET801 2.8 20.0 1.0 CD1 E:PHE543 3.1 20.0 1.0 CE1 E:PHE543 3.2 20.0 1.0 CD2 D:LEU662 3.9 20.0 1.0 C20 E:6ET801 4.0 20.0 1.0 C25 E:6ET801 4.0 20.0 1.0 CB D:ALA665 4.1 20.0 1.0 CG E:PHE543 4.4 20.0 1.0 CE1 D:PHE591 4.5 20.0 1.0 C19 E:6ET801 4.5 20.0 1.0 CG2 D:ILE661 4.5 20.0 1.0 CZ E:PHE543 4.6 20.0 1.0 H201 E:6ET801 4.7 20.0 1.0 H251 E:6ET801 4.7 20.0 1.0

Y.Gao, E.Cao, D.Julius, Y.Cheng. TRPV1 Structures in Nanodiscs Reveal Mechanisms of Ligand and Lipid Action. Nature V. 534 347 2016.
ISSN: ESSN 1476-4687
PubMed: 27281200
DOI: 10.1038/NATURE17964