Chlorine in PDB 5iv3: Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate and the Allosteric Inhibitor LRE1
Enzymatic activity of Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate and the Allosteric Inhibitor LRE1
All present enzymatic activity of Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate and the Allosteric Inhibitor LRE1:
4.6.1.1;
4.6.1.1;
Protein crystallography data
The structure of Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate and the Allosteric Inhibitor LRE1, PDB code: 5iv3
was solved by
S.Kleinboelting,
C.Steegborn,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 44.61 / 1.86 |
| Space group | P 63 |
| Cell size a, b, c (Å), α, β, γ (°) | 100.032, 100.032, 98.658, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 17.6 / 22.3 |
Other elements in 5iv3:
The structure of Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate and the Allosteric Inhibitor LRE1 also contains other interesting chemical elements:
| Calcium | (Ca) | 1 atom |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate and the Allosteric Inhibitor LRE1
(pdb code 5iv3). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate and the Allosteric Inhibitor LRE1, PDB code: 5iv3:
Jump to Chlorine binding site number: 1; 2;
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate and the Allosteric Inhibitor LRE1, PDB code: 5iv3:
Jump to Chlorine binding site number: 1; 2;
Chlorine binding site 1 out of 2 in 5iv3
Go back to
Chlorine Binding Sites List in 5iv3
Chlorine binding site 1 out
of 2 in the Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate and the Allosteric Inhibitor LRE1
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate and the Allosteric Inhibitor LRE1 within 5.0Å range:
|
Chlorine binding site 2 out of 2 in 5iv3
Go back to
Chlorine Binding Sites List in 5iv3
Chlorine binding site 2 out
of 2 in the Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate and the Allosteric Inhibitor LRE1
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Crystal Structure of Human Soluble Adenylyl Cyclase in Complex with Alpha,Beta-Methyleneadenosine-5'-Triphosphate and the Allosteric Inhibitor LRE1 within 5.0Å range:
|
Reference:
L.Ramos-Espiritu,
S.Kleinboelting,
F.A.Navarrete,
A.Alvau,
P.E.Visconti,
F.Valsecchi,
A.Starkov,
G.Manfredi,
H.Buck,
C.Adura,
J.H.Zippin,
J.Van Den Heuvel,
J.F.Glickman,
C.Steegborn,
L.R.Levin,
J.Buck.
Discovery of LRE1 As A Specific and Allosteric Inhibitor of Soluble Adenylyl Cyclase. Nat.Chem.Biol. V. 12 838 2016.
ISSN: ESSN 1552-4469
PubMed: 27547922
DOI: 10.1038/NCHEMBIO.2151
Page generated: Sat Dec 12 11:51:43 2020
ISSN: ESSN 1552-4469
PubMed: 27547922
DOI: 10.1038/NCHEMBIO.2151
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