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Chlorine in PDB 5jap: Exploitation of A Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-Pla2) Discovered Through X-Ray Fragment Screening
Enzymatic activity of Exploitation of A Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-Pla2) Discovered Through X-Ray Fragment Screening
All present enzymatic activity of Exploitation of A Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-Pla2) Discovered Through X-Ray Fragment Screening:
3.1.1.47;
3.1.1.47;
Protein crystallography data
The structure of Exploitation of A Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-Pla2) Discovered Through X-Ray Fragment Screening, PDB code: 5jap
was solved by
P.J.Day,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 44.24 / 2.46 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 99.927, 90.661, 51.303, 90.00, 111.55, 90.00 |
| R / Rfree (%) | 17.3 / 24.6 |
Other elements in 5jap:
The structure of Exploitation of A Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-Pla2) Discovered Through X-Ray Fragment Screening also contains other interesting chemical elements:
| Calcium | (Ca) | 1 atom |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Exploitation of A Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-Pla2) Discovered Through X-Ray Fragment Screening
(pdb code 5jap). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Exploitation of A Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-Pla2) Discovered Through X-Ray Fragment Screening, PDB code: 5jap:
In total only one binding site of Chlorine was determined in the Exploitation of A Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-Pla2) Discovered Through X-Ray Fragment Screening, PDB code: 5jap:
Chlorine binding site 1 out of 1 in 5jap
Go back to
Chlorine Binding Sites List in 5jap
Chlorine binding site 1 out
of 1 in the Exploitation of A Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-Pla2) Discovered Through X-Ray Fragment Screening
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Exploitation of A Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-Pla2) Discovered Through X-Ray Fragment Screening within 5.0Å range:
|
Reference:
A.J.Woolford,
J.E.Pero,
S.Aravapalli,
V.Berdini,
J.E.Coyle,
P.J.Day,
A.M.Dodson,
P.Grondin,
F.P.Holding,
L.Y.Lee,
P.Li,
E.S.Manas,
J.Marino,
A.C.Martin,
B.W.Mccleland,
R.L.Mcmenamin,
C.W.Murray,
C.E.Neipp,
L.W.Page,
V.K.Patel,
F.Potvain,
S.Rich,
R.A.Rivero,
K.Smith,
D.O.Somers,
L.Trottet,
R.Velagaleti,
G.Williams,
R.Xie.
Exploitation of A Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered Through X-Ray Fragment Screening. J.Med.Chem. V. 59 5356 2016.
ISSN: ISSN 0022-2623
PubMed: 27167608
DOI: 10.1021/ACS.JMEDCHEM.6B00212
Page generated: Fri Jul 26 09:54:22 2024
ISSN: ISSN 0022-2623
PubMed: 27167608
DOI: 10.1021/ACS.JMEDCHEM.6B00212
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