Chlorine in PDB 5jo3: PDE5A For NAV1.7

All present enzymatic activity of PDE5A For NAV1.7:
3.1.4.35;

The structure of PDE5A For NAV1.7, PDB code: 5jo3 was solved by I.Storer, J.Chrencik, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	44.00 / 1.49
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	55.840, 76.100, 80.920, 90.00, 102.56, 90.00
R / Rfree (%)	18 / 20.1

The structure of PDE5A For NAV1.7 also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Chlorine atom in the PDE5A For NAV1.7 (pdb code 5jo3). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the PDE5A For NAV1.7, PDB code: 5jo3:

Chlorine binding site 1 out of 1 in the PDE5A For NAV1.7


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of PDE5A For NAV1.7 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl903 b:18.7 occ:1.00 CL9 B:6LK903 0.0 18.7 1.0 C8 B:6LK903 1.7 14.0 1.0 C7 B:6LK903 2.7 14.5 1.0 C3 B:6LK903 2.7 13.2 1.0 O2 B:6LK903 2.9 12.6 1.0 O B:LEU765 3.2 9.5 1.0 O B:HOH1080 3.3 12.6 1.0 C B:LEU765 3.6 8.9 1.0 CA B:LEU765 3.7 8.5 1.0 OH B:TYR612 3.7 13.6 1.0 CB B:ALA767 3.9 8.7 1.0 N B:ILE768 3.9 8.9 1.0 N4 B:6LK903 3.9 12.6 1.0 C6 B:6LK903 4.0 11.9 1.0 O B:HOH1100 4.1 17.4 1.0 CD2 B:LEU765 4.2 12.6 1.0 N B:ALA767 4.2 9.1 1.0 CB B:ILE768 4.3 9.5 1.0 CB B:LEU765 4.3 9.0 1.0 C1 B:6LK903 4.3 14.3 1.0 O B:ASP764 4.4 9.4 1.0 C5 B:6LK903 4.4 12.1 1.0 CA B:ALA767 4.4 8.3 1.0 C B:ALA767 4.6 8.9 1.0 N B:SER766 4.6 9.3 1.0 CA B:ILE768 4.6 9.7 1.0 O B:HOH1196 4.7 25.9 1.0 CZ B:TYR612 4.7 11.7 1.0 N B:LEU765 4.9 8.6 1.0 CG B:LEU765 4.9 9.6 1.0 CG2 B:ILE768 5.0 10.8 1.0

A.Bell, A.Bent, P.Bradley, P.Erdman, M.De Groot, R.Lewthwaite, I.Marsh, S.Ransley, N.Sciammetta, R.Smith, N.Swain, R.Torella, I.Storer. PDE5A For NAV1.7 To Be Published.