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Chlorine in PDB 5jsw: Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3A'R,6'R,6A'R)-2,2,2',2'-Tetramethyldihydro-3A'H- Spiro[[1,3]Dioxolane-4,4'-Furo[3,4-D][1,3]Dioxol]-6'-Yl)Methyl) Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)-One
Enzymatic activity of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3A'R,6'R,6A'R)-2,2,2',2'-Tetramethyldihydro-3A'H- Spiro[[1,3]Dioxolane-4,4'-Furo[3,4-D][1,3]Dioxol]-6'-Yl)Methyl) Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)-One
All present enzymatic activity of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3A'R,6'R,6A'R)-2,2,2',2'-Tetramethyldihydro-3A'H- Spiro[[1,3]Dioxolane-4,4'-Furo[3,4-D][1,3]Dioxol]-6'-Yl)Methyl) Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)-One:
2.4.2.29;
2.4.2.29;
Protein crystallography data
The structure of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3A'R,6'R,6A'R)-2,2,2',2'-Tetramethyldihydro-3A'H- Spiro[[1,3]Dioxolane-4,4'-Furo[3,4-D][1,3]Dioxol]-6'-Yl)Methyl) Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)-One, PDB code: 5jsw
was solved by
F.R.Ehrmann,
D.Nguyen,
A.Heine,
G.Klebe,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 30.16 / 1.22 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 90.336, 64.956, 70.782, 90.00, 96.38, 90.00 |
| R / Rfree (%) | 12.5 / 14.4 |
Other elements in 5jsw:
The structure of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3A'R,6'R,6A'R)-2,2,2',2'-Tetramethyldihydro-3A'H- Spiro[[1,3]Dioxolane-4,4'-Furo[3,4-D][1,3]Dioxol]-6'-Yl)Methyl) Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)-One also contains other interesting chemical elements:
| Zinc | (Zn) | 1 atom |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3A'R,6'R,6A'R)-2,2,2',2'-Tetramethyldihydro-3A'H- Spiro[[1,3]Dioxolane-4,4'-Furo[3,4-D][1,3]Dioxol]-6'-Yl)Methyl) Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)-One
(pdb code 5jsw). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3A'R,6'R,6A'R)-2,2,2',2'-Tetramethyldihydro-3A'H- Spiro[[1,3]Dioxolane-4,4'-Furo[3,4-D][1,3]Dioxol]-6'-Yl)Methyl) Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)-One, PDB code: 5jsw:
In total only one binding site of Chlorine was determined in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3A'R,6'R,6A'R)-2,2,2',2'-Tetramethyldihydro-3A'H- Spiro[[1,3]Dioxolane-4,4'-Furo[3,4-D][1,3]Dioxol]-6'-Yl)Methyl) Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)-One, PDB code: 5jsw:
Chlorine binding site 1 out of 1 in 5jsw
Go back to
Chlorine Binding Sites List in 5jsw
Chlorine binding site 1 out
of 1 in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3A'R,6'R,6A'R)-2,2,2',2'-Tetramethyldihydro-3A'H- Spiro[[1,3]Dioxolane-4,4'-Furo[3,4-D][1,3]Dioxol]-6'-Yl)Methyl) Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)-One
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 6- Amino-2-((((3A'R,6'R,6A'R)-2,2,2',2'-Tetramethyldihydro-3A'H- Spiro[[1,3]Dioxolane-4,4'-Furo[3,4-D][1,3]Dioxol]-6'-Yl)Methyl) Amino)-1H-Imidazo[4,5-G]Quinazolin-8(7H)-One within 5.0Å range:
|
Reference:
F.R.Ehrmann,
E.Schaefer,
A.Heine,
F.Diederich,
G.Klebe.
Application of Carbohydrates Based Lin-Benzoguanines in A Solvent-Exposed Subpocket of the Trna-Modifying Enzyme Tgt To Be Published.
Page generated: Fri Jul 26 10:15:05 2024
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