Atomistry » Chlorine » PDB 5jsr-5jzk » 5jt5
Atomistry »
  Chlorine »
    PDB 5jsr-5jzk »
      5jt5 »

Chlorine in PDB 5jt5: Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 2- ((2-Morpholinoethyl)Amino)-1H-Benzo[D]Imidazole-5-Carboxamide

Enzymatic activity of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 2- ((2-Morpholinoethyl)Amino)-1H-Benzo[D]Imidazole-5-Carboxamide

All present enzymatic activity of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 2- ((2-Morpholinoethyl)Amino)-1H-Benzo[D]Imidazole-5-Carboxamide:
2.4.2.29;

Protein crystallography data

The structure of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 2- ((2-Morpholinoethyl)Amino)-1H-Benzo[D]Imidazole-5-Carboxamide, PDB code: 5jt5 was solved by F.R.Ehrmann, A.Heine, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.80 / 1.21
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 90.293, 65.276, 70.641, 90.00, 96.12, 90.00
R / Rfree (%) 13.5 / 15.7

Other elements in 5jt5:

The structure of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 2- ((2-Morpholinoethyl)Amino)-1H-Benzo[D]Imidazole-5-Carboxamide also contains other interesting chemical elements:

Zinc (Zn) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 2- ((2-Morpholinoethyl)Amino)-1H-Benzo[D]Imidazole-5-Carboxamide (pdb code 5jt5). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 2- ((2-Morpholinoethyl)Amino)-1H-Benzo[D]Imidazole-5-Carboxamide, PDB code: 5jt5:

Chlorine binding site 1 out of 1 in 5jt5

Go back to Chlorine Binding Sites List in 5jt5
Chlorine binding site 1 out of 1 in the Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 2- ((2-Morpholinoethyl)Amino)-1H-Benzo[D]Imidazole-5-Carboxamide


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Trna Guanine Transglycosylase (Tgt) in Co-Crystallized Complex with 2- ((2-Morpholinoethyl)Amino)-1H-Benzo[D]Imidazole-5-Carboxamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl405

b:16.1
occ:0.66
 O A:HOH521 2.6 50.1 1.0
OG1 A:THR285 3.0 15.8 1.0
O A:HOH574 3.1 23.4 1.0
NH1 A:ARG289 3.3 18.7 1.0
CB A:THR285 3.6 15.2 1.0
N A:ARG286 3.8 15.9 0.6
N A:ARG286 3.8 16.2 0.4
NH2 A:ARG289 3.9 21.7 1.0
CB A:VAL282 4.0 16.5 1.0
CD A:LYS52 4.0 19.5 1.0
CZ A:ARG289 4.1 19.7 1.0
CB A:ARG286 4.1 17.9 0.4
CB A:ARG286 4.1 18.3 0.6
CA A:ARG286 4.2 16.6 0.6
CE A:LYS52 4.2 22.4 1.0
CA A:ARG286 4.2 16.9 0.4
CG1 A:VAL282 4.2 18.5 1.0
O A:VAL282 4.3 15.1 1.0
C A:THR285 4.3 15.6 1.0
CG A:LYS52 4.4 16.2 1.0
CA A:THR285 4.5 15.2 1.0
CA A:VAL282 4.6 15.2 1.0
NE A:ARG286 4.7 26.7 0.6
CG2 A:THR285 4.7 16.4 1.0
CB A:LYS52 4.7 14.3 1.0
OG1 A:THR47 4.8 35.9 1.0
C A:VAL282 4.9 14.6 1.0
O A:HOH671 4.9 17.4 1.0

Reference:

F.R.Ehrmann, C.Hohn, A.Heine, F.Diederich, G.Klebe. Benzimidazole-Based Inhibitors As A Novel Scaffold to Inhibit Z.Mobilis Tgt and Study Protein Flexibility and the Contributions of Active Site Residues to Binding Affinity of Lin-Benzopurines. To Be Published.
Page generated: Sat Dec 12 11:54:20 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy