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Atomistry » Chlorine » PDB 5jzl-5k92 » 5k4j | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 5jzl-5k92 » 5k4j » |
Chlorine in PDB 5k4j: Crystal Structure of CDK2 in Complex with Compound 22Enzymatic activity of Crystal Structure of CDK2 in Complex with Compound 22
All present enzymatic activity of Crystal Structure of CDK2 in Complex with Compound 22:
2.7.11.22; Protein crystallography data
The structure of Crystal Structure of CDK2 in Complex with Compound 22, PDB code: 5k4j
was solved by
J.Yin,
W.Wang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5k4j:
The structure of Crystal Structure of CDK2 in Complex with Compound 22 also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of CDK2 in Complex with Compound 22
(pdb code 5k4j). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of CDK2 in Complex with Compound 22, PDB code: 5k4j: Chlorine binding site 1 out of 1 in 5k4jGo back to Chlorine Binding Sites List in 5k4j
Chlorine binding site 1 out
of 1 in the Crystal Structure of CDK2 in Complex with Compound 22
Mono view Stereo pair view
Reference:
J.F.Blake,
M.Burkard,
J.Chan,
H.Chen,
K.J.Chou,
D.Diaz,
D.A.Dudley,
J.J.Gaudino,
S.E.Gould,
J.Grina,
T.Hunsaker,
L.Liu,
M.Martinson,
D.Moreno,
L.Mueller,
C.Orr,
P.Pacheco,
A.Qin,
K.Rasor,
L.Ren,
K.Robarge,
S.Shahidi-Latham,
J.Stults,
F.Sullivan,
W.Wang,
J.Yin,
A.Zhou,
M.Belvin,
M.Merchant,
J.Moffat,
J.B.Schwarz.
Discovery of (S)-1-(1-(4-Chloro-3-Fluorophenyl)-2-Hydroxyethyl) -4-(2-((1-Methyl-1H-Pyrazol-5-Yl)Amino)Pyrimidin-4-Yl) Pyridin-2(1H)-One (Gdc-0994), An Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development. J.Med.Chem. V. 59 5650 2016.
Page generated: Sat Dec 12 11:55:33 2020
ISSN: ISSN 0022-2623 PubMed: 27227380 DOI: 10.1021/ACS.JMEDCHEM.6B00389 |
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