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Atomistry » Chlorine » PDB 5jzl-5k92 » 5k7k | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 5jzl-5k92 » 5k7k » |
Chlorine in PDB 5k7k: Design and Optimization of Biaryl Ether Aryl Sulfonamides As Selective Inhibitors of NAV1.7: Discovery of Clinical Candidate Pf-05089771Enzymatic activity of Design and Optimization of Biaryl Ether Aryl Sulfonamides As Selective Inhibitors of NAV1.7: Discovery of Clinical Candidate Pf-05089771
All present enzymatic activity of Design and Optimization of Biaryl Ether Aryl Sulfonamides As Selective Inhibitors of NAV1.7: Discovery of Clinical Candidate Pf-05089771:
1.14.13.80; Protein crystallography data
The structure of Design and Optimization of Biaryl Ether Aryl Sulfonamides As Selective Inhibitors of NAV1.7: Discovery of Clinical Candidate Pf-05089771, PDB code: 5k7k
was solved by
N.Swain,
J.Chrencik,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5k7k:
The structure of Design and Optimization of Biaryl Ether Aryl Sulfonamides As Selective Inhibitors of NAV1.7: Discovery of Clinical Candidate Pf-05089771 also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Design and Optimization of Biaryl Ether Aryl Sulfonamides As Selective Inhibitors of NAV1.7: Discovery of Clinical Candidate Pf-05089771
(pdb code 5k7k). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Design and Optimization of Biaryl Ether Aryl Sulfonamides As Selective Inhibitors of NAV1.7: Discovery of Clinical Candidate Pf-05089771, PDB code: 5k7k: Chlorine binding site 1 out of 1 in 5k7kGo back to Chlorine Binding Sites List in 5k7k
Chlorine binding site 1 out
of 1 in the Design and Optimization of Biaryl Ether Aryl Sulfonamides As Selective Inhibitors of NAV1.7: Discovery of Clinical Candidate Pf-05089771
Mono view Stereo pair view
Reference:
N.A.Swain,
D.Batchelor,
S.Beaudoin,
B.M.Bechle,
P.A.Bradley,
A.D.Brown,
B.Brown,
K.J.Butcher,
R.P.Butt,
M.L.Chapman,
S.Denton,
D.Ellis,
S.R.G.Galan,
S.M.Gaulier,
B.S.Greener,
M.J.De Groot,
M.S.Glossop,
I.K.Gurrell,
J.Hannam,
M.S.Johnson,
Z.Lin,
C.J.Markworth,
B.E.Marron,
D.S.Millan,
S.Nakagawa,
A.Pike,
D.Printzenhoff,
D.J.Rawson,
S.J.Ransley,
S.M.Reister,
K.Sasaki,
R.I.Storer,
P.A.Stupple,
C.W.West.
Discovery of Clinical Candidate 4-[2-(5-Amino-1H-Pyrazol-4-Yl) -4-Chlorophenoxy]-5-Chloro-2-Fluoro-N-1, 3-Thiazol-4-Ylbenzenesulfonamide (Pf-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides As Selective Inhibitors of NAV1.7. J. Med. Chem. V. 60 7029 2017.
Page generated: Sat Dec 12 11:55:39 2020
ISSN: ISSN 1520-4804 PubMed: 28682065 DOI: 10.1021/ACS.JMEDCHEM.7B00598 |
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