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Atomistry » Chlorine » PDB 5kga-5kor » 5kgt » |
Chlorine in PDB 5kgt: Crystal Structure of 7,8-Diaminopelargonic Acid Synthase (Bioa) From Mycobacterium Tuberculosis, Complexed with An Inhibitor Optimized From Hts Lead: 1-[4-[4-(3-Chlorophenyl)Carbonylpiperidin-1- Yl]Phenyl]EthanoneEnzymatic activity of Crystal Structure of 7,8-Diaminopelargonic Acid Synthase (Bioa) From Mycobacterium Tuberculosis, Complexed with An Inhibitor Optimized From Hts Lead: 1-[4-[4-(3-Chlorophenyl)Carbonylpiperidin-1- Yl]Phenyl]Ethanone
All present enzymatic activity of Crystal Structure of 7,8-Diaminopelargonic Acid Synthase (Bioa) From Mycobacterium Tuberculosis, Complexed with An Inhibitor Optimized From Hts Lead: 1-[4-[4-(3-Chlorophenyl)Carbonylpiperidin-1- Yl]Phenyl]Ethanone:
2.6.1.62; Protein crystallography data
The structure of Crystal Structure of 7,8-Diaminopelargonic Acid Synthase (Bioa) From Mycobacterium Tuberculosis, Complexed with An Inhibitor Optimized From Hts Lead: 1-[4-[4-(3-Chlorophenyl)Carbonylpiperidin-1- Yl]Phenyl]Ethanone, PDB code: 5kgt
was solved by
K.M.Maize,
A.Divakaran,
C.C.Aldrich,
B.C.Finzel,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of 7,8-Diaminopelargonic Acid Synthase (Bioa) From Mycobacterium Tuberculosis, Complexed with An Inhibitor Optimized From Hts Lead: 1-[4-[4-(3-Chlorophenyl)Carbonylpiperidin-1- Yl]Phenyl]Ethanone
(pdb code 5kgt). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of 7,8-Diaminopelargonic Acid Synthase (Bioa) From Mycobacterium Tuberculosis, Complexed with An Inhibitor Optimized From Hts Lead: 1-[4-[4-(3-Chlorophenyl)Carbonylpiperidin-1- Yl]Phenyl]Ethanone, PDB code: 5kgt: Chlorine binding site 1 out of 1 in 5kgtGo back to Chlorine Binding Sites List in 5kgt
Chlorine binding site 1 out
of 1 in the Crystal Structure of 7,8-Diaminopelargonic Acid Synthase (Bioa) From Mycobacterium Tuberculosis, Complexed with An Inhibitor Optimized From Hts Lead: 1-[4-[4-(3-Chlorophenyl)Carbonylpiperidin-1- Yl]Phenyl]Ethanone
Mono view Stereo pair view
Reference:
F.Liu,
S.Dawadi,
K.M.Maize,
R.Dai,
S.W.Park,
D.Schnappinger,
B.C.Finzel,
C.C.Aldrich.
Structure-Based Optimization of Pyridoxal 5'-Phosphate-Dependent Transaminase Enzyme (Bioa) Inhibitors That Target Biotin Biosynthesis in Mycobacterium Tuberculosis. J. Med. Chem. V. 60 5507 2017.
Page generated: Sat Dec 12 11:56:31 2020
ISSN: ISSN 1520-4804 PubMed: 28594172 DOI: 10.1021/ACS.JMEDCHEM.7B00189 |
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