Atomistry » Chlorine » PDB 5l55-5l77 » 5l5x
Atomistry »
  Chlorine »
    PDB 5l55-5l77 »
      5l5x »

Chlorine in PDB 5l5x: Yeast 20S Proteasome with Human BETA5C (1-138) and Human BETA6 (97- 111; 118-133) in Complex with Onx 0914

Enzymatic activity of Yeast 20S Proteasome with Human BETA5C (1-138) and Human BETA6 (97- 111; 118-133) in Complex with Onx 0914

All present enzymatic activity of Yeast 20S Proteasome with Human BETA5C (1-138) and Human BETA6 (97- 111; 118-133) in Complex with Onx 0914:
3.4.25.1;

Protein crystallography data

The structure of Yeast 20S Proteasome with Human BETA5C (1-138) and Human BETA6 (97- 111; 118-133) in Complex with Onx 0914, PDB code: 5l5x was solved by M.Groll, E.M.Huber, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 15.00 / 2.90
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 136.020, 300.510, 145.450, 90.00, 112.97, 90.00
R / Rfree (%) 17.9 / 21.5

Other elements in 5l5x:

The structure of Yeast 20S Proteasome with Human BETA5C (1-138) and Human BETA6 (97- 111; 118-133) in Complex with Onx 0914 also contains other interesting chemical elements:

Magnesium (Mg) 9 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Yeast 20S Proteasome with Human BETA5C (1-138) and Human BETA6 (97- 111; 118-133) in Complex with Onx 0914 (pdb code 5l5x). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Yeast 20S Proteasome with Human BETA5C (1-138) and Human BETA6 (97- 111; 118-133) in Complex with Onx 0914, PDB code: 5l5x:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 5l5x

Go back to Chlorine Binding Sites List in 5l5x
Chlorine binding site 1 out of 2 in the Yeast 20S Proteasome with Human BETA5C (1-138) and Human BETA6 (97- 111; 118-133) in Complex with Onx 0914


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Yeast 20S Proteasome with Human BETA5C (1-138) and Human BETA6 (97- 111; 118-133) in Complex with Onx 0914 within 5.0Å range:
probe atom residue distance (Å) B Occ
G:Cl302

b:52.5
occ:1.00
OH H:TYR69 2.8 50.9 1.0
NH1 G:ARG111 3.0 52.6 1.0
OD1 G:ASN114 3.2 63.1 1.0
CD G:ARG111 3.5 52.6 1.0
CE2 H:TYR69 3.6 51.8 1.0
CZ H:TYR69 3.6 52.2 1.0
CB G:ASN114 3.7 56.9 1.0
CG G:ASN114 3.9 59.3 1.0
CZ G:ARG111 4.0 52.9 1.0
NE G:ARG111 4.2 52.6 1.0
CA G:ARG111 4.6 55.1 1.0
O G:ARG111 4.8 56.7 1.0
CG G:ARG111 4.8 53.9 1.0
CD2 H:TYR69 4.9 51.4 1.0
CE1 H:TYR69 4.9 51.3 1.0
CB G:ARG111 5.0 55.0 1.0

Chlorine binding site 2 out of 2 in 5l5x

Go back to Chlorine Binding Sites List in 5l5x
Chlorine binding site 2 out of 2 in the Yeast 20S Proteasome with Human BETA5C (1-138) and Human BETA6 (97- 111; 118-133) in Complex with Onx 0914


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Yeast 20S Proteasome with Human BETA5C (1-138) and Human BETA6 (97- 111; 118-133) in Complex with Onx 0914 within 5.0Å range:
probe atom residue distance (Å) B Occ
U:Cl301

b:49.8
occ:1.00
OH V:TYR69 2.9 54.2 1.0
NH1 U:ARG111 3.0 59.1 1.0
OD1 U:ASN114 3.2 55.8 1.0
CD U:ARG111 3.7 56.6 1.0
CE2 V:TYR69 3.7 56.9 1.0
CB U:ASN114 3.7 56.4 1.0
CZ V:TYR69 3.7 56.3 1.0
CG U:ASN114 3.8 57.0 1.0
CZ U:ARG111 4.0 58.4 1.0
NE U:ARG111 4.3 59.4 1.0
CA U:ARG111 4.7 54.2 1.0
O U:ARG111 4.8 59.2 1.0
CD2 V:TYR69 5.0 56.2 1.0
CG U:ARG111 5.0 54.8 1.0

Reference:

E.M.Huber, W.Heinemeyer, G.De Bruin, H.S.Overkleeft, M.Groll. A Humanized Yeast Proteasome Identifies Unique Binding Modes of Inhibitors For the Immunosubunit Beta 5I. Embo J. V. 35 2602 2016.
ISSN: ESSN 1460-2075
PubMed: 27789522
DOI: 10.15252/EMBJ.201695222
Page generated: Sat Dec 12 12:00:12 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy