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Chlorine in PDB 5l6a: Yeast 20S Proteasome with Mouse BETA5I (1-138) and Mouse BETA6 (97- 111; 118-133) in Complex with Epoxyketone Inhibitor 17
Enzymatic activity of Yeast 20S Proteasome with Mouse BETA5I (1-138) and Mouse BETA6 (97- 111; 118-133) in Complex with Epoxyketone Inhibitor 17
All present enzymatic activity of Yeast 20S Proteasome with Mouse BETA5I (1-138) and Mouse BETA6 (97- 111; 118-133) in Complex with Epoxyketone Inhibitor 17:
3.4.25.1;
3.4.25.1;
Protein crystallography data
The structure of Yeast 20S Proteasome with Mouse BETA5I (1-138) and Mouse BETA6 (97- 111; 118-133) in Complex with Epoxyketone Inhibitor 17, PDB code: 5l6a
was solved by
M.Groll,
E.M.Huber,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 15.00 / 2.80 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 134.330, 300.520, 145.190, 90.00, 112.66, 90.00 |
| R / Rfree (%) | 18.6 / 21.3 |
Other elements in 5l6a:
The structure of Yeast 20S Proteasome with Mouse BETA5I (1-138) and Mouse BETA6 (97- 111; 118-133) in Complex with Epoxyketone Inhibitor 17 also contains other interesting chemical elements:
| Magnesium | (Mg) | 8 atoms |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Yeast 20S Proteasome with Mouse BETA5I (1-138) and Mouse BETA6 (97- 111; 118-133) in Complex with Epoxyketone Inhibitor 17
(pdb code 5l6a). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Yeast 20S Proteasome with Mouse BETA5I (1-138) and Mouse BETA6 (97- 111; 118-133) in Complex with Epoxyketone Inhibitor 17, PDB code: 5l6a:
Jump to Chlorine binding site number: 1; 2;
In total 2 binding sites of Chlorine where determined in the Yeast 20S Proteasome with Mouse BETA5I (1-138) and Mouse BETA6 (97- 111; 118-133) in Complex with Epoxyketone Inhibitor 17, PDB code: 5l6a:
Jump to Chlorine binding site number: 1; 2;
Chlorine binding site 1 out of 2 in 5l6a
Go back to
Chlorine Binding Sites List in 5l6a
Chlorine binding site 1 out
of 2 in the Yeast 20S Proteasome with Mouse BETA5I (1-138) and Mouse BETA6 (97- 111; 118-133) in Complex with Epoxyketone Inhibitor 17
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Yeast 20S Proteasome with Mouse BETA5I (1-138) and Mouse BETA6 (97- 111; 118-133) in Complex with Epoxyketone Inhibitor 17 within 5.0Å range:
|
Chlorine binding site 2 out of 2 in 5l6a
Go back to
Chlorine Binding Sites List in 5l6a
Chlorine binding site 2 out
of 2 in the Yeast 20S Proteasome with Mouse BETA5I (1-138) and Mouse BETA6 (97- 111; 118-133) in Complex with Epoxyketone Inhibitor 17
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of Yeast 20S Proteasome with Mouse BETA5I (1-138) and Mouse BETA6 (97- 111; 118-133) in Complex with Epoxyketone Inhibitor 17 within 5.0Å range:
|
Reference:
E.M.Huber,
W.Heinemeyer,
G.De Bruin,
H.S.Overkleeft,
M.Groll.
A Humanized Yeast Proteasome Identifies Unique Binding Modes of Inhibitors For the Immunosubunit Beta 5I. Embo J. V. 35 2602 2016.
ISSN: ESSN 1460-2075
PubMed: 27789522
DOI: 10.15252/EMBJ.201695222
Page generated: Sat Dec 12 12:01:05 2020
ISSN: ESSN 1460-2075
PubMed: 27789522
DOI: 10.15252/EMBJ.201695222
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